Development of the method of treatment for neuropathic pain -Basic study of the effect of iontophoresis-
| Project/Area Number |
22592253
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SHIMADA Masahiko 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (40170948)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZAKI Yoko 東京医科歯科大学, 歯学部附属病院, 助教 (90366609)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ACイオントフォレーシス / DCイオントフォレーシス / 神経因性疼痛 / CCI / Fos / 脳・神経 / イオントフォレーシス |
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| Research Abstract |
This study aimed to compare the effect of alternating current iontophoresis (AC IOP) with direct current iontophoresis (DC IOP). As a result of behavior and immunohistological experiment, DC IOP have a fast onset time and a short effect time, while AC IOP have a slow onset time and a long effect time. According to the result of the blood concentration of lidocaine, we confirmed that those effects were not caused by systemic administration of lidocaine. Additionally, those electrical powers we applied did not lead to extravasation of Evans Blue in the skins under the electrodes.
Thus, these findings of this study suggest that AC IOP is useful for patients suffering from chronic pain because of its long effect time.
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Report
(5 results)
Research Products
(7 results)
