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Analysis of pathological and/or unphysiological root resorption mechanism focused on the two types of osteoclasts

Research Project

Project/Area Number 22592274
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionHokkaido University

Principal Investigator

YOSHIMURA Yoshitaka  北海道大学, 大学院・歯学研究科, 助教 (30230816)

Co-Investigator(Kenkyū-buntansha) DOMON Takanori  北海道大学, 大学院・歯学研究科, 教授 (50217618)
KIKUIRI Takashi  北海道大学, 大学院・歯学研究科, 助教 (10322819)
Co-Investigator(Renkei-kenkyūsha) DEYAMA Yoshiaki  北海道大学, 大学院・歯学研究科, 准教授 (80271667)
HASEGAWA Tomokazu  徳島大学, 大学病院, 講師 (50274668)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords破骨細胞 / 歯学 / 歯根吸収
Research Abstract

In this study, we examined the pathological and/or unphysiologicalroot resorption mechanism focused on the two types of osteoclasts. Our results weresuggested that morphologic characteristics of the osteoclasts varied according to thedown-regulation of Treg activity, difference of the major histocompatibility complex(MHC) haplotype, tensile force in culture condition and ROS scavengers.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2013 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (2 results)

  • [Journal Article] Short-term mechanical stress inhibits osteoclastogenesis via suppression of DC-STAMP in RAW264.7 cells2013

    • Author(s)
      Sumika Kameyama, Yoshitaka Yoshimura,Takeshi Kameyama, Takashi Kikuiri, Mino Matsuno, Yoshiaki Deyama, Kuniaki Suzuki,Junichiro Iida
    • Journal Title

      International Journal of Molecular Medicine

      Volume: 31巻 Issue: 2 Pages: 292-298

    • DOI

      10.3892/ijmm.2012.1220

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of bisphosphonates on osteoclastogenesis in RAW264.7 cells2012

    • Author(s)
      Abe K, Yoshimura Y, Deyama Y, et al
    • Journal Title

      International Journal of Molecular Medicine

      Volume: 29 Pages: 1007-1015

    • DOI

      10.3892/ijmm.2012.952

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stage-dependent suppression of the formation of dentin-resorbing multinuclear cells with MIF in vitro2011

    • Author(s)
      Kikuiri T, Yoshimura Y, Tabata F, Hasegawa T, Nishihira J, Shirakawa T
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 3 Issue: 1 Pages: 37-43

    • DOI

      10.3892/etm.2011.362

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Platinum Nanoparticles Suppress Osteoclastogenesis Through Scavenging of Reactive Oxygen Species Produced in RAW264.7 Cells2011

    • Author(s)
      Nomura M, Yoshimura Y, Kikuiri T, Hasegawa T, Taniguchi Y, Deyama Y, Koshiro K, Sano H, Suzuki K, Inoue N.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 117 Issue: 4 Pages: 243-252

    • DOI

      10.1254/jphs.11099FP

    • NAID

      10030453660

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of the release from mechanical stress on osteoclastogenesis in RAW 264. 7 cells2011

    • Author(s)
      Shibata K, Yoshimura Y, Kikuiri T, Hasegawa T, Taniguchi Y, Deyama Y, Suzuki K, Iida J.
    • Journal Title

      Int J Molecular Medicin

      Volume: 28 Pages: 73-79

    • DOI

      10.3892/ijmm.2011.675

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of the release from mechanical stress on osteoclastogenesis in RAW264.7 cells.2011

    • Author(s)
      Kenjiro Shibata
    • Journal Title

      International Journal of Molecular Medicine

      Volume: (印刷中,印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 破骨細胞分化に対する白金ナノコロイドの影響2010

    • Author(s)
      野村真有美
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 機械的刺激からの解放が破骨細胞分化に与える影響2010

    • Author(s)
      芝田健二郎
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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