| Project/Area Number |
22616005
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Mechanobiology
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
LI Qinkai 徳島大学, 病院, 特任助教 (10571531)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUNAKI Makoto 徳島大学, 病院, 特任教授 (10467821)
HATA Akiko 徳島大学, 病院, 学術研究員 (20570948)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 細胞外基質 / 硬度 / 脂肪細胞 / 慢性炎症 / 細胞外基質問 / 弾性 |
|---|
| Research Abstract |
We previously reported that 3T3-L1 adipocytes exhibit palmitate-induced proinflammatory response most prominently, when they are seeded on 2 -D matrices, which have a stiffness that correspond to that of obese adipose tissues. We then analyzed how mechanical properties of the matrices affect adipocyte functions, when they are seeded in a 3-D environment. Here we report that not only the stiffness of the matrices but also compression of the matrices regulate adipocyte functions.
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