| Project/Area Number |
22650068
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | National Institute for Physiological Sciences |
|---|
Principal Investigator |
TOMITA Koichi 生理学研究所, 行動・代謝分子解析センター, 特任助教 (80314285)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,160,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
|
|---|
| Keywords | 分子・細胞神経科学 / 神経可塑性 / 神経科学 / 感覚認知 |
|---|
| Research Abstract |
The aim of this project is elucidating the role of ocular dominance(OD) columns during the depth perception. The mouse, devoid of OD columns, is normally weak in discriminating the visual distance. We originally found that a short form of molecular chaperone, which has a neurite-promoting activity, showed specific expression to the ipsilateral OD columns of the developing visual cortex in higher mammals. To directly test the role of OD columns in the depth perception, I am now investigating whether overexpression of ispilateral OD column-specific chaperone can induce OD columns in mouse visual cortex and, moreover, whether this mouse can show increased ability to discriminate the visual distance.
|
