Prevention of ulcerative colitis by cigarettesmoking: Development of a novel therapeutic strategy using genetically engineered mice

• Project/Area Number: 22651020
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: University of Yamanashi
• Principal Investigator: KITAMURA Masanori 山梨大学, 大学院・医学工学総合研究部, 教授 (90333062)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,700,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥600,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 喫煙 / タバコ煙 / 芳香族炭化水素受容体 / 潰瘍性大腸炎 / 遺伝子改変マウス / シグナル伝達 / 免疫担当細胞 / 治療 / 漬瘍性大腸炎 / DSS腸炎

Research Abstract

Cigarette smoking is a known factor that attenuates onset and progression of ulcerative colitis (UC). In the present investigation, we have conducted a study to examine our working hypothesis that cigarette smoking attenuates UC through

Research Products

• [Journal Article] Pathological in situ reprogramming of somatic cells by the unfolded protein response (2013)
  • Author(s): Johno H and Kitamura M
  • Journal Title: Am J Pathol Volume: (in press)
  • Peer Reviewed
• [Journal Article] The unfolded protein response triggered by environmental factors (2013)
  • Author(s): Kitamura M
  • Journal Title: Semin Immunopathol Volume: 35 Pages: 259-275
  • Peer Reviewed
• [Journal Article] Intervention in genotoxic stress-induced senescence by cordycepin through activation of eIF2αand suppression of Sp1 (2013)
  • Author(s): Gu L,Johno H, Nakajima S, Yoshitomi T, Takahashi S, and Kitamura M
  • Journal Title: Toxicol Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] Eviprostat activates cAMP signaling pathway and suppresses bladder smooth muscle cell proliferation (2013)
  • Author(s): Li K, Yao J, Chi Y, Sawada N, Araki I, Kitamura M, and Takeda M
  • Journal Title: Int J Mol Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] Pleiotropic potential of DHMEQ for NF-κB suppression via reactive oxygen species and unfolded protein response (2013)
  • Author(s): Nakajima S, Kato H,Gu L, Takahashi S,Johno H, Umezawa K, and Kitamura M
  • Journal Title: J Immuno Volume: (in press)
  • Peer Reviewed
• [Journal Article] Dual regulation of cadmium-induced apoptosis by mTORC1 through selective induction of IRE1 branches in unfolded protein response (2013)
  • Author(s): Kato H, Katoh R, and Kitamura M
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] Connexin43 hemichannel-mediated regulation of connexin43 (2013)
  • Author(s): Li K, Chi Y, Gao K, Yan Q, Matsue H, Takeda T, Kitamura M, and Yao J
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] Blockade of Smad signaling by 3 '-deoxyadenosine: a mechanism for its anti-fibrotic potential (2013)
  • Author(s): Gu L, Johno H, Nakajima S, Kato H, Takahashi H, Katoh K, and Kitamura M
  • Journal Title: Lab Invest Volume: 93 Pages: 450-461
  • Peer Reviewed
• [Journal Article] Grape seed extract from "Koshu" cultivar antagonizes dioxin-induced aryl hydrocarbon receptor activation. (2013)
  • Author(s): Sugiyama T, Kitamura M, Sugita K, Okuda T, Hisamoto M, and Nakao A
  • Journal Title: Am J Enol Viticult Volume: (in press)
  • Peer Reviewed
• [Journal Article] Pleiotropic potential of DHMEQ for NF-κB suppression via reactive oxygen species and unfolded protein response (2013)
  • Author(s): Nakajima S
  • Journal Title: J Immunol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Dual regulation of cadmium-induced apoptosis by mTORC1 through selective induction of IRE1 branches in unfolded protein response (2013)
  • Author(s): Kato H
  • Journal Title: PLoS One Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Connexin43 hemichannel-mediated regulation of connexin43 (2013)
  • Author(s): Li K
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] Blockade of Smad signaling by 3 '-deoxyadenosine: a mechanism for its anti-fibrotic potential (2013)
  • Author(s): Gu L, Johno H, Nakajima S, Kato H, Takahashi H, Katoh K, and Kitamura M
  • Journal Title: Lab Invest Volume: 93 Issue: 4 Pages: 450-461
  • DOI: 10.1038/labinvest.2013.4
  • Peer Reviewed
• [Journal Article] Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay (2012)
  • Author(s): Gu L, and Kitamura M
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] Unfolded protein response causes a phenotypic shift of inflamed glomerular cells towards redifferentiation through dual blockade of Akt and Smad signaling pathways (2012)
  • Author(s): Johno H, Nakajima S,Kato H,Yao J, Paton AW, Paton JC, Katoh R, Shimizu F, and Kitamura M
  • Journal Title: Am J Pathol Volume: 181 Pages: 1977-1990
  • Peer Reviewed
• [Journal Article] NADPH oxidase-mediated upregulation of connexin43 contributes to podocyte injury (2012)
  • Author(s): Yan Q, Gao K, Chi Y, Li K, Zhu Y, Wan Y,Sun W,Matsue H, Kitamura M, and Yao Y
  • Journal Title: Free Rad Biol Med Volume: 53 Pages: 1286-1297
  • Peer Reviewed
• [Journal Article] Blockade of adipocyte differentiation by cordycepin (2012)
  • Author(s): Takahashi S, Tamai T, Nakajima S, Kato H, Johno H, Nakamura T, and Kitamura M
  • Journal Title: British J Pharmacol Volume: 167 Pages: 561-575
  • Peer Reviewed
• [Journal Article] Acidic stress-ER stress axis for blunted activation of NF-κB in mesothelial cells exposed to peritoneal dialysis fluid (2012)
  • Author(s): Johno H, Ogata R, Nakajima S, Hiramatsu N, Kobayashi T, Hara H, and Kitamura M
  • Journal Title: Nephrol Dial Transplant Volume: 27 Pages: 4053-4060
  • Peer Reviewed
• [Journal Article] Cordycepin as a sensitizer to TNF-α-induced apoptosis through eIF2α- and mTORC1- mediated inhibition of NF-κB (2012)
  • Author(s): Kadomatsu M, Nakajima S, Kato H, Gu L, Chi Y, Yao J and Kitamura M
  • Journal Title: Clin Exp Immunol Volume: 168 Pages: 325-332
  • Peer Reviewed
• [Journal Article] β-catenin signaling contributes to PDGF-elicited bladder smooth muscle cell contraction through up-regulation of Cx43 expression (2012)
  • Author(s): Li K, Yao J, Sawada N, Kitamura M, Andersson K-E, and Takeda M
  • Journal Title: J Urol Volume: 188 Pages: 307-315
  • Peer Reviewed
• [Journal Article] mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway (2012)
  • Author(s): Kato H, Nakajima S, Saito Y, Takahashi S, Katoh R, and Kitamura M
  • Journal Title: Cell Death Differ Volume: 19 Pages: 310-320
  • Peer Reviewed
• [Journal Article] Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay (2012)
  • Author(s): Gu L, and Kitamura M
  • Journal Title: PLoS One Volume: 7 Issue: 12 Pages: e52305-e52305
  • DOI: 10.1371/journal.pone.0052305
  • Peer Reviewed
• [Journal Article] Acidic stress - ER stress axis for blunted activation of NF-κB in mesothelial cells exposed to peritoneal dialysis fluid (2012)
  • Author(s): Johno H, Ogata R, Nakajima S, Hiramatsu N, Kobayashi T, Hara H, and Kitamura M
  • Journal Title: Nephrol Dial Transplant Volume: 27 Issue: 11 Pages: 4053-4060
  • DOI: 10.1093/ndt/gfs130
  • Peer Reviewed
• [Journal Article] Control of NF-κB and inflammation by the unfolded protein response (2011)
  • Author(s): Kitamura M
  • Journal Title: Int Rev Immunol Volume: 30 Pages: 4-15
• [Journal Article] Real-time monitoring of ER stress in living cells and animals using ESTRAP assay (2011)
  • Author(s): Kitamura M, and Hiramatsu N
  • Journal Title: Methods in Enzymology(UPR and Cell Stress Volume: Chapter 5
• [Journal Article] 小胞体ストレスとメサンギウムの細胞応答 (2011)
  • Author(s): 北村正敬
  • Journal Title: Annual Review 腎臓 Pages: 30-37
• [Journal Article] Aryl hydrocarbon receptor 経路の活性化によるデキストラン硫酸ナトリウム誘導性大腸炎の抑制 (2011)
  • Author(s): 高村武之、原間大輔、下川直美、北村正敬、中尾篤人
  • Journal Title: 消化器と免疫 Volume: 47 Pages: 76-79
• [Journal Article] Reciprocal regulation between proinflammatory cytokine-induced iNOS and connexin43 in bladder smooth muscle cells (2011)
  • Author(s): Li K, Yao J, Shi L, Sawada N, Chi Y, Yan Q, Fukayama M, Zakohji H, Araki I, Kitamura Mand Takeda M
  • Journal Title: J Biol Chem Volume: 286 Pages: 41552-41562
  • Peer Reviewed
• [Journal Article] Dysfunction of corneas and lacrimal glands in smoking model rat (2011)
  • Author(s): Higuchi A, Ito K, Dogru M, Kitamura M, Kawakita T, Ogawa Y, and Tsubota K
  • Journal Title: Free Rad Biol Med Volume: 51 Pages: 2210-2216
  • Peer Reviewed
• [Journal Article] Nonsteroidal anti- inflammatory drug flufenamic acid is a potent activator of AMPK (2011)
  • Author(s): Chi Y, Li K, Yan Q, Koizumi S, Shi L, Takahashi S, Zhu Y, Matsue H, Takeda M, Kitamura M, Yao J
  • Journal Title: J Pharmacol Exp Ther Volume: 339 Pages: 257-266
  • Peer Reviewed
• [Journal Article] Oscillation of mitogen- activated protein kinases in response to endoplasmic reticulum stress (2011)
  • Author(s): Zhang H, Zhao Y,TianT, Paton AW, Paton JC, Kitamura M
  • Journal Title: Anal Biochem Volume: 417 Pages: 292-294
  • Peer Reviewed
• [Journal Article] Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin. (2011)
  • Author(s): Tian T, Zhao Y, Nakajima S, Huang T, Yao J, Paton AW, Paton JC and Kitamura M
  • Journal Title: Biochem Biophys Res Commun Volume: 410 Pages: 852-858
  • Peer Reviewed
• [Journal Article] Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK - eIF2αpathway (2011)
  • Author(s): Tagawa Y, Hiramatsu N, Kato H, Sakoh T, Nakajima S, Hayakawa K, Saito Y, Johno H, Takahashi S, Gu L, Yao J, and Kitamura M
  • Journal Title: Toxicology Volume: 287 Pages: 105-112
  • Peer Reviewed
• [Journal Article] Inhibition of NF-κB by MG132 through ER stress-mediated induction of LAP and LIP (2011)
  • Author(s): Nakajima S, Kato H, Takahashi S, Johno H, and Kitamura M
  • Journal Title: FEBS Lett Volume: 585 Pages: 2249-2254
  • Peer Reviewed
• [Journal Article] Aberrant, differential and bidirectional regulation of the unfolded protein response towards cell survival by 3'-deoxyadenosine (2011)
  • Author(s): Kitamura M, Kato H, Saito Y, Nakajima S, Takahashi S, Johno H, Gu L, and Katoh R
  • Journal Title: Cell Death Differ Volume: 18 Pages: 1876-1888
  • Peer Reviewed
• [Journal Article] Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR: involvement of C/EBPβand mTOR- dependent dephosphorylation of Akt (2011)
  • Author(s): Nakajima S, HiramatsuN, Hayakawa K, Saito Y, Kato H, Huang T, Yao J, Paton AW, Paton JC, and Kitamura M
  • Journal Title: Mol Cell Biol Volume: 31 Pages: 1710-1718
  • Peer Reviewed
• [Journal Article] Lactobacillus bulgaricusOLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis. (2011)
  • Author(s): Takamura T, Harama D, Fukumoto S, Nakamura Y, Shimokawa N, Ohshima K, Ikegami S, Makino S, Kitamura M, and Nakao A
  • Journal Title: Immunol Cell Bioll Volume: 89 Pages: 817-822
  • Peer Reviewed
• [Journal Article] Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response (2011)
  • Author(s): Zhao Y,Tian T, Huang T,Nakajima S, Saito Y, Takahashi S, Yao J, Paton AW, PatonJC, and Kitamura M
  • Journal Title: Toxicol Sci Volume: 120 Pages: 79-86
  • Peer Reviewed
• [Journal Article] Impairment of MCP-1 expression in mesothelial cells exposed to PDF by osmotic stress and acidic stress (2011)
  • Author(s): Ogata R, Hiramatsu N, Hayakawa K, Nakajima S, Yao J, Kobayashi T, and Kitamura M
  • Journal Title: Perit Dial Int Volume: 31 Pages: 80-89
  • Peer Reviewed
• [Journal Article] Lactobacillus bulgaricusOLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis (2011)
  • Author(s): Takamura T, Harama D, Fukumoto S, Nakamura Y, Shimokawa N, Ohshima K, Ikegami S, Makino S, Kitamura M, and Nakao A
  • Journal Title: Immunol Cell Bioll Volume: 89 Issue: 7 Pages: 817-822
  • DOI: 10.1038/icb.2010.165
  • Peer Reviewed
• [Journal Article] Aryl hydrocarbon receptor経路の活性化によるデキストラン硫酸ナトリウム誘導性大腸炎の抑制 (2011)
  • Author(s): 高村武之, ほか
  • Journal Title: 消化器と免疫 Volume: 47 Pages: 76-79
• [Journal Article] Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis. (2011)
  • Author(s): Takamura T, et al.
  • Journal Title: Immunol Cell Biol Volume: In press(In press)
  • Peer Reviewed
• [Journal Article] Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR: involvement of C/EBPss and mTOR-dependent dephosphorylation of Akt. (2011)
  • Author(s): Nakajima S, et al.
  • Journal Title: Mol Cell Biol Volume: 31 Pages: 1710-1718
  • Peer Reviewed
• [Journal Article] Connexin43 hemichannels contribute to cadmium-induced oxidative stress and cell injury (2010)
  • Author(s): Fang X, Huang T, ZhuY, Jiang JX, Wang P, Kitamura M and Yao J
  • Journal Title: Antioxid Redox Signal Volume: 14 Pages: 2427-2439
  • Peer Reviewed
• [Journal Article] The oxidative stress - endoplasmic reticulum stress axis in cadmium toxicity (2010)
  • Author(s): Kitamura M, and Hiramatsu N
  • Journal Title: Biometals Volume: 23 Pages: 941-950
• [Journal Article] Induction of the unfolded protein response by calcineurin inhibitors: A double-edged sword in renal transplantation. (2010)
  • Author(s): Kitamura M
  • Journal Title: Nephrol Dial Transplant Volume: 25 Pages: 6-9
  • Peer Reviewed
• [Journal Article] Anti- inflammatory subtilase cytotoxin up-regulates A20 through the unfolded protein response (2010)
  • Author(s): Nakajima S,Saito Y, Takahashi S, Hiramatsu N, Kato H,Johno H, Yao J,Paton AW, Paton JC, and Kitamura M
  • Journal Title: Biochem Biophys Res Commun Volume: 397 Pages: 176-180
  • Peer Reviewed
• [Journal Article] Selective deletion of adipocytes, but not preadipocytes, by TNF-α via C/EBP- and PPARγ-mediated suppression of NF-κB (2010)
  • Author(s): Tamai M, Shimada T, Hiramatsu N, Hayakawa K, Okamura M, Tagawa Y, Takahashi S, Nakajima S, Yao S, and Kitamura M:
  • Journal Title: Lab Invest Volume: 90 Pages: 1385-1395
  • Peer Reviewed
• [Journal Article] Disruption of gap junction attenuates aminoglycoside- elicited renal tubular cell injury (2010)
  • Author(s): Yao J, Huang T, Fang X, Chi Y, Zhu Y, Wan Y, Matsue H, and Kitamura M
  • Journal Title: Br J Pharmacol Volume: 160 Pages: 2055-2068
  • Peer Reviewed
• [Journal Article] Suppression of nephrin expression by TNF-α via interfering with the cAMP - retinoic acid receptor pathway (2010)
  • Author(s): Saito Y, Okamura M, Nakajima S, Hayakawa K, Huang T, Yao J, and Kitamura M
  • Journal Title: Am J Physiol-Renal Volume: 298
  • Peer Reviewed
• [Journal Article] Activation of the arylhydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice (2010)
  • Author(s): Takamura T, Harama D, Matsuoka S, Shimokawa N, Nakamura Y, Okumura K, Ogawa H, Kitamura M, and Nakao A
  • Journal Title: Immunol Cell Biol Volume: 88 Pages: 685-689
  • Peer Reviewed
• [Journal Article] Influences of acidic conditions on formazan assay: A cautionary note. (2010)
  • Author(s): Johno H, Takahashi S, and Kitamura M
  • Journal Title: Appl Biochem Biotech Volume: 162 Pages: 1529-1535
  • Peer Reviewed
• [Journal Article] Gap junctions sensitize cancer cells to proteasome inhibitor MG132-induced apoptosis (2010)
  • Author(s): Huang T, Zhu Y, Fang X, Chi Y, Kitamura M, and Yao J
  • Journal Title: Cancer Sci Volume: 101 Pages: 713-721
  • NAID: 10026589655
  • Peer Reviewed
• [Journal Article] ER stress depresses NF-κB activation in mesangial cells through preferential induction of C/EBPβ. (2010)
  • Author(s): Hayakawa K, Nakajima S, Hiramatsu N, Okamura M, Huang T, Saito Y, Tagawa Y, Tamai M, Takahashi S, Yao J, and Kitamura M
  • Journal Title: J Am Soc Nephrol Volume: 21 Pages: 73-81
  • Peer Reviewed
• [Journal Article] Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice. (2010)
  • Author(s): Takamura T, et al.
  • Journal Title: Immunol Cell Biol Volume: 88 Pages: 685-689
  • Peer Reviewed
• [Presentation] 4-フェニル酪酸類縁体による小胞体ストレス応答の制御 (2013)
  • Author(s): 張卉
  • Organizer: 第93回日本化学会春季年会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス（草津）
• [Presentation] ストレスが導く細胞のリプログラミング (2013)
  • Author(s): 城野悠志
  • Organizer: 第２回サイエンス・インカレ
  • Place of Presentation: 幕張メッセ国際会議場（幕張）
• [Presentation] Dual regulation of cadmium-induced apoptosis by mTORC1 through induction of selective unfolded protein response (2012)
  • Author(s): Kato H,Nakajima S and Kitamura M
  • Organizer: 45th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-11-03
• [Presentation] Phenotypic shift of activated glomerular cells towards redifferentiation by the unfolded protein response (2012)
  • Author(s): Johno H, Nakajima S,Kato H,Yao J, and Kitamura M
  • Organizer: 45th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego, November
  • Year and Date: 2012-11-03
• [Presentation] Blockade of Smad signaling by 3'-deoxyadenosine: A mechanism for the anti-fibrotic potential (2012)
  • Author(s): Gu L, Johno H, Nakajima S,Kato H,and Kitamura M
  • Organizer: 45th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-11-02
• [Presentation] Pleiotropic potential of DHMEQ for NF-κB suppression: Implications for oxidative stress and unfolded protein response (2012)
  • Author(s): Nakajima S
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡）
• [Presentation] Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay (2012)
  • Author(s): Gu L
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡）
• [Presentation] Aryl hydrocarbon receptpr経路の活性化によるデキストラン硫酸ナトリウム誘導性大腸炎の抑制 (2010)
  • Author(s): 高村武之, ほか
  • Organizer: 第47回日本消化器免疫学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-07-08
• [Presentation] 喫煙による眼球表面への影響 (2010)
  • Author(s): 樋口明弘、伊藤香織、ムラト・ドール、北村正敬、坪田一男
  • Organizer: 第33回日本分子生物学会年会/第83回日本生化学会大会合同大会 BMB2010
  • Place of Presentation: 神戸
• [Presentation] Induction of CHOP by cigarette smoke through the superoxide anion-triggered PERK - eIF2αpathway (2010)
  • Author(s): Tagawa Y, Nakajima S, Kato H, and Kitamura M
  • Organizer: 第33回日本分子生物学会年会/第83回日本生化学会大会合同大会 BMB2010
  • Place of Presentation: 神戸
• [Presentation] Anti-inflammatory potential of subtilase cytotoxin: Dual suppression of NF-κB via induction of C/EBPβand mTOR- mediated dephosphorylation of Akt (2010)
  • Author(s): Nakajima S,Huang T, Yao J, and Kitamura M
  • Organizer: 43rd Annual Meeting of American Society of Nephrology
  • Place of Presentation: Denver, USA
• [Presentation] Connexin hemichannels mediate low calcium-elicited activation of cAMP signaling pathway and elevation of renin production in juxtaglomerular cells (2010)
  • Author(s): Huang T, Nakajima S, Kitamura M, Yao J
  • Organizer: 43rd Annual Meeting of American Society of Nephrology
  • Place of Presentation: Denver, USA
• [Presentation] Connexin43 hemichannels exaggerate cadmium-induced oxidative stress and cell injury in renal tubular epithelial cells (2010)
  • Author(s): Yao J, Sun W, Huang T, Nakajima S, and Kitamura M
  • Organizer: 43rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Denver, USA
• [Presentation] Upregulation of connexin43 expression and function in urinary bladder by inflammatory cytokines (2010)
  • Author(s): Li K, Sawada N, Yao J, Nakagomi H, Miyamoto T, Kira S, Araki I, Kitamura M, and Takeda M
  • Organizer: Joint Annual Meeting of International Continence Society and the International Urogynecological Association
  • Place of Presentation: Toronto, Canada
• [Presentation] Platelet-derived growth factor-mediated upregulation of connexin43 in bladder smooth muscle cells: A possible role in urinary bladder overactivity (2010)
  • Author(s): Sawada N, Li K, Yao J, Miyamoto T, Nakagomi H, Kira S, Kobayashi H, Tsuchida T, Araki I, Kitamura M, and Takeda M
  • Organizer: Joint Annual Meeting of International Continence Society and the International Urogynecological Association
  • Place of Presentation: Toronto, Canada
• [Presentation] Aryl hydrocarbon receptor経路の活性化によるデキストラン硫酸ナトリウム誘導性大腸炎の抑制 (2010)
  • Author(s): 高村武之、原間大輔、下川直美、北村正敬、中尾篤人
  • Organizer: 第47回日本消化器免疫学会総会
  • Place of Presentation: 滋賀
• [Presentation] Connexin43 hemichannel-mediated release of ATP suppresses AMPK activation in renal tubular epithelial cells
  • Author(s): Chi Y
  • Organizer: 45th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego Convention Center (San Diego, USA)
• [Presentation] Dual regulation of cadmium-induced apoptosis by mTORC1 through induction of selective unfolded protein response
  • Author(s): Kato H
  • Organizer: 45th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego Convention Center (San Diego, USA)
• [Presentation] Blockade of Smad signaling by 3’-deoxyadenosine: A mechanism for the anti-fibrotic potential
  • Author(s): Gu L
  • Organizer: 45th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego Convention Center (San Diego, USA)
• [Presentation] Phenotypic shift of activated glomerular cells towards redifferentiation by the unfolded protein response
  • Author(s): Johno H
  • Organizer: 45th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego Convention Center (San Diego, USA)
• [Presentation] NADPH oxidase-mediated up-regulation of connexin43 contributes to the oxidative stress-elicited podocyte injury
  • Author(s): Gao K
  • Organizer: 第55回日本腎臓学会総会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] β-catenin signaling contributes to PDGF-elicited bladder smooth muscle cell contraction through upregulation of Cx43 expression.
  • Author(s): Li K
  • Organizer: 2012 Annual Meeting of American Urology Association
  • Place of Presentation: Georgia World Congress Center (Atlanta, USA)
• [Book] Methods in Enzymology(UPR and Cell Stress)Vol.490, Chapter 5: Real-time monitoring of ER stress in living cells and animals using ESTRAP assay. (2011)
  • Author(s): Kitamura M, Hiramatsu N
  • Publisher: Academic Press(Elsevier)
• [Remarks] 分子情報伝達学講座HP
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  • URL: http://www.med.yamanashi.ac.jp/lifescience/
• [Remarks] 分子情報伝達学講座ホームページ
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