| Project/Area Number |
22658035
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied biochemistry
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| Research Institution | Ishikawa Prefectural University |
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Principal Investigator |
YAMAMOTO Kenji 石川県立大学, 生物資源環境学部, 教授 (70109049)
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| Co-Investigator(Kenkyū-buntansha) |
ASHIDA Hisashi 京都大学, 大学院・生命科学研究科, 准教授 (40379087)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,560,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | インフルエンザウイルス / 感染阻害剤 / シアロ糖鎖 / アルギン酸 / キトサン / インフルエンザウィルス / シアリルラクトース / MDCK細胞 / エンド-M / シアロ糖鎖ポリマー / 免疫蛍光抗体法 |
|---|
| Research Abstract |
We have succeeded in simple syntheses of efficient binding-inhibitors for influenza virus, which are composed of sialyl saccharides of glycopeptides extracted from hen egg yolk. We modified alginate and chitosan with multiple sialyl saccharides using condensation reaction and reductive amination reaction, respectively. These binding-inhibitors utilize the carbohydrate recognition of influenza virus for sialic acid, thus they can prevent the virus from infection. The resulting inhibitors showed sufficient inhibitory activity against influenza virus infection in MDCK cells. Unlike the other binding-inhibitors of influenza virus, these virus inhibitors require simple step in their syntheses.
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