| Budget Amount *help |
¥3,060,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Research Abstract |
This study has aimed at the development of photochromic DNA binding ligands for B Z-DNA interconversion. It has been shown from SPR and ITC measurements that the P[ 5] helicene ligand has higher affinity to B-DNA and the M-[ 5] helicene ligand dose to Z-DNA. The bisary ligand with the azobenzene unit and the naphthalene unit induced B-Z transition, and Z-DNA was returned to B-DNA by UV irradiation. Thus, this study has shown the first example of the photochromic ligand for B-Z conversion.
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