Photochromic DNA Binding Ligands for B and Z-DNA Interconversion
| Project/Area Number |
22659004
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,060,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 生体関連物質 / ZーDNAォトクロミックリガンド / DNA高次構造 / Z-DNA / フォトクロミックリガンド |
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| Research Abstract |
This study has aimed at the development of photochromic DNA binding ligands for B Z-DNA interconversion. It has been shown from SPR and ITC measurements that the P[ 5] helicene ligand has higher affinity to B-DNA and the M-[ 5] helicene ligand dose to Z-DNA. The bisary ligand with the azobenzene unit and the naphthalene unit induced B-Z transition, and Z-DNA was returned to B-DNA by UV irradiation. Thus, this study has shown the first example of the photochromic ligand for B-Z conversion.
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Report
(3 results)
Research Products
(27 results)
