Development of anti-HIV agents using chemical genomics based on viral self-regulation mechanism
| Project/Area Number |
22659021
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
TAMAMURA Hirokazu 東京医科歯科大学, 生体材料工学研究所, 教授 (80217182)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,700,000 (Direct Cost: ¥1,700,000)
|
|---|
| Keywords | インテグラーゼ阻害剤 / マトリックス蛋白 / CD4ミミック / アンタゴニスト / HIV / CXCR4 |
|---|
| Research Abstract |
Several anti-HIV agents have been developed using forward and reverse chemical gemomics. 1) Helical mimetics and staple peptides of Vpr-fragments were synthesized and found to have potent integrase inhibitory activity. 2) Several matrix fragments with cell membrane penetrating signal having anti-HIV activity were developed. 3) Novel CD4 mimic derivatives having potent anti-HIV activity which cause conformational change of gp120 were found. 4) New CXCR4 antagonists with xylene scaffold were developed.
|
Report
(3 results)
Research Products
(140 results)
-
-
-
-
-
-
-
-
[Journal Article] Evaluation of a Synthetic C34 Trimer of HIV-1 gp41 as AIDS Vaccines2012
Author(s)
Hashimoto, C., Nomura, W., Ohya, A., Urano, E., Miyauchi, K., Narumi, T., Aikawa, H., Komano, J.A., Yamamoto, N., Tamamura, H.
-
Journal Title
Bioorg.Med.Chem.
Volume: (in press)
Issue: 10
Pages: 3287-3291
DOI
Related Report
Peer Reviewed
-
[Journal Article] Effects of DNA Binding of Zinc Finger and Linkers for Domain Fusion on Catalytic Activity of Sequence-Specific Chimeric Recombinases Determined by a Facile Fluorescent System2012
Author(s)
Nomura, W., Masuda, A., Ohba, K., Urabe, A., Ito, N., Ryo, A., Yamamoto, N., Tamamura, H.
-
Journal Title
Biochemistry
Volume: 51
Issue: 7
Pages: 1510-1517
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
