Modeling and experimental verification of skull suture pattern formation

• Project/Area Number: 22659035
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Kyoto University
• Principal Investigator: MIURA Takashi 京都大学, 大学院・医学研究科, 准教授 (10324617)
• Co-Investigator(Kenkyū-buntansha): OGIHARA Naomichi 慶応大学, 大学院・理工学部, 講師 (70324605)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,080,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: パターン形成 / 縫合線 / 反応拡散 / μCT 応用数理 / 頭蓋骨 / 数理モデル / 界面方程式 / 数理解析 / 頭蓋骨縫合線

Research Abstract

We formulated new type of pattern formation model of skull suture interdigitation. The model consist of interface equation with convolution kernel. We undertook detailed numerical analysis, and based on the analysis we could reproduce biological patterns which are not undertaken before.

Research Products

• [Journal Article] Turing and Wolpert work together during limb development (2013)
  • Author(s): Miura T
  • Journal Title: Sci Signaling Volume: 6 Pages: 14-14
• [Journal Article] Turing and Wolpert work together during limb development (2013)
  • Author(s): Miura T
  • Journal Title: Science Signaling Volume: 6 Issue: 270 Pages: 14-14
  • DOI: 10.1126/scisignal.2004038
  • Peer Reviewed
• [Journal Article] Modeling lung branching morphogenesis via epithelial-mesenchymal interaction (2011)
  • Author(s): Miura T
  • Journal Title: Dev Biol Volume: 365 Pages: 143-143
• [Journal Article] 固定された脊椎動物モデルの NMR スペクトルと MRI 画像の検討 (2011)
  • Author(s): 桑原航
  • Journal Title: 電子情報通 信学会技術研究報告 Volume: 110 Pages: 173-178
• [Journal Article] Modeling lung branching morphogenesis via epithelial-mesenchymal interaction (2011)
  • Author(s): Miura T.
  • Journal Title: Developmental Biology Volume: 356 Pages: 143-143
• [Presentation] 頭蓋骨縫合線のパターン形成の数理モデル化とその実験的検証 (2013)
  • Organizer: 生命科学プロジェクトゼミナール・特別シンポジウム バイオインフォマティクスと数理モデル
  • Place of Presentation: 熊本
  • Year and Date: 2013-01-16
• [Presentation] 頭蓋骨縫合線のパターン形成の数理モデル化とその実験的検証 (2013)
  • Author(s): 三浦岳
  • Organizer: 生命科学プロジェクトゼミナール・特別シンポジウム バイオインフォマティクスと数理モデル
  • Place of Presentation: 熊本
  • Invited
• [Presentation] 頭蓋骨の縫合線のパターン形成 (2012)
  • Organizer: 日本植物学会
  • Place of Presentation: 姫路
  • Year and Date: 2012-09-16
• [Presentation] Diffusion in development: its relationship with spontaneous pattern formation、Turing Symposium on Morphogenesis --Mathematica (2012)
  • Organizer: Approaches Sixty Years after Alan Turing
  • Place of Presentation: 仙台
  • Year and Date: 2012-08-28
• [Presentation] 頭蓋骨縫合線のパターン形成:発生と数理をつなぐ (2012)
  • Organizer: Evo-Devo 若手の会
  • Place of Presentation: 岡崎
  • Year and Date: 2012-06-16
• [Presentation] 頭蓋骨縫合線のパターン形成：発生と数理をつなぐ (2012)
  • Author(s): 三浦 岳
  • Organizer: Evo-Devo若手の会
  • Place of Presentation: 岡崎
• [Presentation] Diffusion in development: its relationship with spontaneous pattern formation. (2012)
  • Author(s): 三浦岳
  • Organizer: Turing Symposium on Morphogenesis --Mathematical Approaches Sixty Years after Alan Turing
  • Place of Presentation: 仙台
  • Invited
• [Presentation] Diffusion dynamics of vascular endothelial growth factor during in vitro vasculogenesis (2011)
  • Author(s): 三浦岳
  • Organizer: Seeing is Believing-Imaging the Processes of Life
  • Place of Presentation: Heidelberg(英国)
  • Year and Date: 2011-03-20
• [Presentation] Modeling lung branching morphogenesis via epithelial-mesenchymal interaction (2011)
  • Author(s): 三浦岳
  • Organizer: 発生生物学会
  • Place of Presentation: 沖縄
• [Presentation] How well does Turing's theory of morphogenesis work? (2011)
  • Author(s): 三浦 岳
  • Organizer: 数理研研究集会「生物数学の理論とその応用」
  • Place of Presentation: 京都