Development of novel immunotherapy by using of human iPS cells of an antigen-specific T-cell origin
| Project/Area Number |
22659058
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,090,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | 抗原特異的T細胞 / iPS細胞 / 幹細胞 / T細胞の分化誘導 |
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| Research Abstract |
Adoptive immunotherapy with antigen-specific T cells expressing a limited TCR repertoire is a promising approach to fighting various types of cancer and chronic viral infections ; however, the effectiveness of this therapy declines due to exhaustion of the antigen-specific T cells. To overcome this problem, we have explored the potential of induced pluripotent stem(iPS) cell technology and have generated T cell-derived iPS(T-iPS) cells. Furthermore, we have succeeded in redifferentiating T-iPS cells into T lineage cells. As was expected, the invariance of the antigen specificity was evidenced by the fact that the TCR gene rearrangement patterns in the redifferentiated T lineage cells were identical to those in the original T cell. These findings suggest that regeneration of antigen-specific immune systems using iPS cell technology will shed new light on the field of adoptive immunotherapy.
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Report
(3 results)
Research Products
(35 results)
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[Journal Article] A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage2012
Author(s)
Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL
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Journal Title
Cell
Volume: 148
Issue: 5
Pages: 1001-1014
DOI
Related Report
Peer Reviewed
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[Journal Article] Development of defective and persistent sendai virus vector : a unique gene delivery/expression system ideal for cell reprogramming2011
Author(s)
Nishimura K, Sano M, Ohtaka M, Furuta B, Umemura Y, Nakajima Y, Ikehara Y, Kobayashi T, Segawa H, Takayasu S, Sato H, Motomura K, Uchida E, Kanayasu-Toyoda T, Asashima M, Nakauchi H, Yamaguchi T, Nakanishi M
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Journal Title
J Biol Chem
Volume: 11
Issue: 6
Pages: 476-71
DOI
Related Report
Peer Reviewed
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[Journal Article] Development of defective and persistent sendai virus vector : a unique gene delivery/expression system ideal for cell reprogramming.2011
Author(s)
Nishimura K, Sano M, Ohtaka M, Furuta B, Umemura Y, Nakajima Y, Ikehara T, Kobayashi T, Segawa H, Takayasu S, Sato H, Motomura K, Uchida E, Kanayasu-Toyoda T, Asashima M, Nakauchi H, Yamaguchi T, Nakanishi M.
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Journal Title
J Biol Chem
Volume: 11
Pages: 4760-71
Related Report
Peer Reviewed
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[Journal Article] Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells.2010
Author(s)
Kobayashi T, Yamaguchi T, Hamanaka S, Kato-Itoh M, Yamazaki Y, Ibata M, Sato H, Lee YS, Usui J, Knisely AS, Hirabayashi M, Nakauchi H.
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Journal Title
Cell
Volume: 3
Pages: 787-99
Related Report
Peer Reviewed
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[Journal Article] Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.2010
Author(s)
Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K.
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Journal Title
J Exp Med
Volume: 20
Pages: 2817-30
Related Report
Peer Reviewed
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[Journal Article] Reduction of N-Glycolylneuraminic Acid in Human Induced Pluripotent Stem Cells Generated or Cultured under Feeder- and Serum-Free Defined Conditions.2010
Author(s)
HayashiY, Chan T, Warashina M, Fukuda M, Ariizumi T, Okabayashi K, Takayama N, Otsu M, Eto K, Furue MK, Michiue T, Ohnuma K, Nakauchi H, Asashima M.
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Journal Title
Related Report
Peer Reviewed
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