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Optimization and standardization of cultivation for human mesenchymal stem cells derived from differential tissues

Research Project

Project/Area Number 22659076
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionNational Research Institute for Child Health and Development

Principal Investigator

HIDA Naoko  独立行政法人国立成育医療研究センター, 生殖・細胞医療研究部, 研究員 (70360112)

Co-Investigator(Kenkyū-buntansha) UMEZAWA Akihiro  独立行政法人国立成育医療研究センター, 生殖・細胞医療研究部, 部長(再生医療センター長) (70213486)
TOYODA Masashi  地方独立行政法人東京都健康長寿医療センター, 研究所老年病研究チーム・血管医学研究, 研究副部長 (50392486)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥600,000 (Direct Cost: ¥600,000)
KeywordsES細胞 / 遺伝子解析 / 再生医療 / 細胞移植 / 移植・再生医療 / 再生医学 / 細胞プロファイリング / 間葉系幹細胞 / 心筋分化 / 間葉系細胞 / 共培養 / プロファイリング / 細胞リソース / 虚血性心疾 / ヒト幹細胞 / バイオリソース
Research Abstract

It has been noted that human mesenchymal stem cells are one of the most suitable cell sources. Mesenchymal stem cells exist in many tissues and differ in their property. In this study, we optimized the cultivation system for clinical purpose. We will improve efficacies of the cell products through information sharing.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] Treatment of human mesenchymal stem cells withangiotensin receptor blocker improved efficiency of cardiomyogenic trans differentiation and improved cardiac function via angiogenesis.2011

    • Author(s)
      Numasawa Y, Kimura T, Miyoshi S, Nishiyama N, Hida N, Tsuji H, Tsuruta H, Segawa K, Ogawa S, Umezawa A
    • Journal Title

      Stem Cells

      Volume: 29(9) Pages: 1405-14

    • Related Report
      2012 Final Research Report
  • [Journal Article] Pretreatment of human mesenchymal stemcells with pioglitazone improved efficiency of cardiomyogenictransdifferentiation and cardiac function.2011

    • Author(s)
      Shinmura D, Togashi I, Miyoshi S, Nishiyama N, Hida N, Tsuji H, Tsuruta H,Segawa K, Tsukada Y, Ogawa S, Umezawa A
    • Journal Title

      Stem Cells

      Volume: 29(2) Pages: 357-66

    • Related Report
      2012 Final Research Report
  • [Journal Article] Pretreatment of Human Mesenchymal Stem Cells with Pioglitazone Improved Efficiency of Cardiomyogenic Transdifferentiation and Improved Cardiac Function2010

    • Author(s)
      Shinmura D., Togashi I., Miyoshi S., Nishiyama N., Hida N., Tsuji H., Tsuruta H., Nakamizo H., Segawa K., Tsukada Y., Ogawa S., Umezawa A.
    • Journal Title

      Stem Cells.

      Volume: 29 Pages: 357-366

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Xenografted human amniotic membrane-derived mesenchymal stem cells are immunologically tolerated and transdifferentiated into cardiomyocytes2010

    • Author(s)
      Tsuji H, Miyoshi S, Ikegami Y, Hida N, Asada H, Togashi I, Suzuki J, Satake M, Nakamizo H, Tanaka M, Mori T, Segawa K, Nishiyama N, Inoue J, Makino H, Miyado K, Ogawa S, Yoshimura Y, Umezawa A.
    • Journal Title

      Circ Res.

      Volume: 28;106(10) Pages: 1613-1623

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum-independent cardiomyogenic transdifferentiation in human endome trium-derived mesenchymal cells.2010

    • Author(s)
      Ikegami Y, Miyoshi S, Nishiyama N, Hida N, Okamoto K, Miyado K, Segawa K, Ogawa S, Umezawa A.
    • Journal Title

      Artif Organs.

      Volume: Apr;34(4) Pages: 280-288

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ピオグリダゾン活性化骨髄間葉系幹細胞移植がイヌ心筋梗塞モデルで心機能を改善する2010

    • Author(s)
      高橋辰郎、古梶清和、三好俊一郎、岡本一真、石田治、木村雄弘、宗形昌儒、村木浩司、稲川浩平、肥田直子、西山信大、新村大輔、梅澤明弘、四津良平
    • Organizer
      第63回日本胸部外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-24
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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