Development of evaluation methods for effects of environmental chemicals on the central nervous systems
| Project/Area Number |
22659120
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Hokkaido University |
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Principal Investigator |
SAITO Takeshi 北海道大学, 大学院・保健科学研究院, 教授 (40153811)
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| Co-Investigator(Kenkyū-buntansha) |
HOSOKAWA Toshiyuki 北海道大学, 高等教育推進機構, 教授 (00157025)
FUJITA Hiroyoshi 北海道大学, 大学院・医学研究科, 教授 (60142931)
YAMAUCHI Taro 北海道大学, 大学院・保健科学研究院, 教授 (70345049)
KURASAKI Masaaki 北海道大学, 大学院・地球環境科学研究院, 助教 (80161727)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,240,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | 環境保健 / 環境汚染化学物質 / 中枢神経系 / 影響評価法 / アポトーシス / DNA切断 / 分化 / 衛生 / 神経伝達物質 |
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| Research Abstract |
We developed evaluation methods for effects of environmental chemicals on the central nervous systems. First of all, the method for the quantification of DNA damage by chemicals in tissues and cultured cells was developed. Using the method, we evaluated apoptotic effects of diethyl phthalate parabens and a stevioside. Secondly, we developed an evaluation method for effects of chemicals on cell differentiation in PC12 cells. In addition, the evaluation method to detect apoptosis induced by metals and chelated metals was developed.
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Report
(4 results)
Research Products
(42 results)
