| Project/Area Number |
22659121
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HITOMI Yoshiaki 金沢大学, 医学系, 准教授 (70231545)
KAMBAYASHI Yasuhiro 金沢大学, 医学系, 講師 (20345630)
日比野 由利 金沢大学, 医学系, 助教 (40362008)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | インフルエンザ / スギ花粉症 / T細胞エピトープ / リポソームワクチン / ペプチドワクチン / α-GalCer / 細胞傷害性Tリンパ球 / Ｔ細胞エピトープ |
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| Research Abstract |
We constructed liposomes vaccines, in α-GalCe, an activated substance in NKT cell was inserted into the bilayers of phospholipid liposome capsules, and T cell epitopes derived from Japanese cedar pollen was included and attached to the surface of CTL epitopes. We examined IFV titers in the model mouse infected by influenza virus and sensitized by Japanese cedar pollen. In results, the administration of the vaccines for 6 days before the infection showed the prophylactic effects.
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