| Project/Area Number |
22659195
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Shimane University |
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Principal Investigator |
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| Research Collaborator |
HASEGAWA Yuki 島根大学, 医学部, 助教 (00362921)
KOBAYASHI Hironori 島根大学, 医学部, 助教 (70397868)
MUSHIMOTO Yuichi 島根大学, 医学部, 助教 (90467712)
PUREVSUREN Jamiyan 島根大学, 医学部, 外国人特別研究員
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,320,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 脂肪酸代謝異常 / インフルエンザ脳症 / 薬剤安全性 / β酸化能 / ベザフィブレート / 急性脳症 |
|---|
| Research Abstract |
There are some drugs which may occasionally toxic for children, despite non-toxic for adults. We use a method, in vitro probe acylcarnitine(IVP) assay, using cultured fibroblasts and tandem mass spectrometry(MS/MS) to evaluate fatty acid oxidation(FAO) capacity and toxicity of drugs. Cells from various FAO disorders(medium-to long-chain disorders) were used, and the following results were obtained : Aspirin(antipyretic), and valproic acid(anti-epileptic drug) potentially caused some inhibition of FAO in cells from impaired FAO patients. Bezafibrate(hypolipidemic drug) significantly improved FAO in cells from FAO disorders. Bezafibrate can be a new treatment option for FAO disorders.
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