| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Research Abstract |
To visualize the temporal and spatial changes of autophagy occurred in the pathogenesis of cerebral infarction and amyotrophic lateral sclerosis(ALS), a transgenic mouse expressing a fused protein of an autophagy marker, LC3 and GFP was used for analysis. The changes of autophagy can be successfully visualized in the model mice of cerebral infarction and ALS. This novel research technique is a useful tool for investigating therapies for both diseases.
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