Analysis of bone regeneration using small-molecule harmine and Id2-knockout mice
| Project/Area Number |
22659356
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
EGUSA Hiroshi 大阪大学, 大学院・歯学研究科, 助教 (30379078)
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| Co-Investigator(Kenkyū-buntansha) |
YATANI Hirofumi 大阪大学, 大学院・歯学研究科, 教授 (80174530)
SAEKI Makio 大阪大学, 大学院・歯学研究科, 講師 (30273692)
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| Co-Investigator(Renkei-kenkyūsha) |
YOKOTA Yoshifumi 福井大学, 医学部, 教授 (50222386)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,220,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | 再生歯学 / harmine / Id2 / 骨芽細胞 / 破骨細胞 / ケミカルバイオロジー / id2 / 骨組織再生 |
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| Research Abstract |
This research project was performed aiming at investigating new molecular mechanisms using Id2-knockout mouse-derived osteoclasts/ osteoblasts and small-molecules. We found that small-molecule harmine is a potent activator of NFATc1 due to its interference with the functions of the protein kinase DYRK1A in osteoclast progenitors, and via its induction of Id2 expression, thus leading to the disruption of the fusion events mediating osteoclastogenesis.
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Report
(3 results)
Research Products
(11 results)
