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Interaction of peripheral reflexes in cardiovascular regulation during exercise

Research Project

Project/Area Number 22680049
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Sports science
Research InstitutionMeiji University

Principal Investigator

ICHINOSE Masashi  明治大学, 経営学部, 准教授 (10551476)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2010: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Keywordsスポーツ生理学 / 循環調節 / 血圧 / 自律神経活動 / 運動 / 運動生理学 / 自律神経 / 末梢反射
Research Abstract

In this study, 1) we established experimental technique to quantify the characteristics of the muscle metaboreflex during dynamic exercise in humans. In addition, 2) we found that during activation of the muscle metaboreflex, the arterial baroreflex-mediated peripheral vasoconstriction is enhanced. Such interaction of the peripheral reflexes could contribute to the cardiovascular regulation during exercise. These findings advance elucidation of mechanisms of cardiovascular regulation during exercise, and will be a significant academic base in considering the safety of exerciseand the efficacy of the exercise training in promotion of health.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (52 results)

All 2013 2012 2011 2010 Other

All Journal Article (17 results) (of which Peer Reviewed: 16 results) Presentation (31 results) Book (4 results)

  • [Journal Article] Muscle metaboreflex activation speeds the recovery of arterial blood pressure following acute hypotension in humans2013

    • Author(s)
      Masashi Ichinose, Kazuhito Watanabe、 Naoto Fujii, Narihiko Kondo and Takeshi Nishiyasu
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: (In press) Issue: 11 Pages: 1568-1575

    • DOI

      10.1152/ajpheart.00833.2012

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Musclemetaboreflex-induced coronary vasoconstriction limits ventricular contractility during dynamic exercise in heart failure2013

    • Author(s)
      Coutsos M,Sala-Mercado JA,Ichinose M,LiZ,Dawe EJ,O'Leary DS
    • Journal Title

      American Journal of Physiology Heart and Circulatory Physiology

      Volume: 304(7) Issue: 7 Pages: 1029-1037

    • DOI

      10.1152/ajpheart.00879.2012

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in arterial blood pressure elicited by severe passive heating at rest is associated with hyperthermia-induced hyperventilation in humans2013

    • Author(s)
      Fujii N. Ichinose M, Honda Y,Tsuji B, Watanabe K, Kondo N & Nishi yasu T
    • Journal Title

      European Journal of Applied Physiology

      Volume: 113 Issue: 1 Pages: 51-62

    • DOI

      10.1007/s00421-012-2413-x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Muscle metaboreflex activation speeds the recovery of arterial blood pressure following acute hypotension in humans.2013

    • Author(s)
      Ichinose M, Watanabe K, Fujii N, Kondo N, Nishiyasu T.
    • Journal Title

      American Journal of Physiology Heart and Circulatory Physiology

      Volume: In Press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic cardiac output regulation at rest, during exercise, and muscle metaboreflex activation: impact of congestive heart failure.2012

    • Author(s)
      Ichinose M,Sala-Mercado JA,Coutsos M,LiZ,Ichinose TK,Dawe E,Fano D,O'Leary DS
    • Journal Title

      American Journal of Physiology Regulatory Integrative and Comparative Physiology

      Volume: 303(7) Issue: 7 Pages: 757-768

    • DOI

      10.1152/ajpregu.00119.2012

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Arterial baroreflex control of muscle sympathetic nerve activity under orthostatic stress in humans.2012

    • Author(s)
      Ichinose M, Nishiyasu T.
    • Journal Title

      Front Physiol.

      Volume: 3 Pages: 314-314

    • DOI

      10.3389/fphys.2012.00314

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cardiovascular regulation during exercise - Contribution of peripheral reflexes2012

    • Author(s)
      Ichinose M,Watanabe K,Fujii N,and Nishiyasu T.
    • Journal Title

      Journal of Physical Fitness and Sports Medicine

      Volume: 1(3) Pages: 437-445

    • NAID

      10031158974

    • URL

      http://dx.doi.org/10.7600/jpfsm.1.437

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Relationships between the extent of apnea-induced bradycardia and thevascular response in the arm and leg during dynamic two-legged knee extension exercise.2012

    • Author(s)
      Nishiyasu T, Tsukamoto R, Kawai K, Hayashi K, Koga S, Ichinose M.
    • Journal Title

      American Journal of Physiology Heart and Circulatory Physiology

      Volume: 302(3) Issue: 3 Pages: 864-871

    • DOI

      10.1152/ajpheart.00413.2011

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sweating responses and the muscle metaboreflex under mildly hyperthermic conditions in sprinters and distance runners2011

    • Author(s)
      Amano T, Ichinose M, Koga S, Inoue Y, Nishiyasu T, Kondo N
    • Journal Title

      J Appl Physiol

      Volume: 111 Issue: 2 Pages: 524-529

    • DOI

      10.1152/japplphysiol.00212.2011

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of muscle metaboreflex function through graded reduction in foreann blood flow during rhythmic handgrip exercise in humans2011

    • Author(s)
      Masashi Ichinose, Stephane Delliaux, Kazuhito Watanabe, Naoto Fujii, Takeshi Nishiyasu
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: VOL.301 Issue: 2 Pages: 609-616

    • DOI

      10.1152/ajpheart.00076.2011

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of CO_2 0n the ventilatory sensitivity to rising body temperature during exercise2011

    • Author(s)
      Hayashi K, Honda Y, Miyakawa N, Fujii N, Ichinose M, Koga S, Kondo N, Nishiyasu T
    • Journal Title

      J Appl Physiol

      Volume: 110 Issue: 5 Pages: 1334-1341

    • DOI

      10.1152/japplphysiol.00010.2010

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Individual differences in the heart rate response to activation of the muscle metaboreflexi n humans2010

    • Author(s)
      Watanabe K,Ichinose M,Fujii N,Matsumoto M,and Nishiyasu T
    • Journal Title

      American Journal of Physiology Heartand Circulatory Physiology

      Volume: 299(5) Issue: 5 Pages: 1708-1714

    • DOI

      10.1152/ajpheart.00255.2010

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Muscle Metaboreflex-Induced Coronary Vasoconstriction Functionally Limits Increases in Ventricular Contractility.2010

    • Author(s)
      Coutsos M, Sala-Mercado JA, Ichinose M, Li Z, Dawe EJ and O'Leary DS.
    • Journal Title

      Journal of Applied Physiology

      Volume: 109(2) Issue: 2 Pages: 271-278

    • DOI

      10.1152/japplphysiol.01243.2009

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic control of maximal ventricular elastance via the baroreflex and force-frequency relation in awake dogs before and after pacing-induced heart failure.2010

    • Author(s)
      Chen X, Sala-Mercado JA, Hammond RL, Ichinose M, Soltani S, Mukkamala R, O'Leary DS.
    • Journal Title

      American Journal of Physiology Heart and Circulatory Physiology

      Volume: 299(1) Issue: 1 Pages: 62-69

    • DOI

      10.1152/ajpheart.00922.2009

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Individual differences in the heart rate response to activation of the muscle metaboreflex in humans.2010

    • Author(s)
      Watanabe K, Ichinose M, Fujii N, Matsumoto M, Nishiyasu T
    • Journal Title

      American Journal of Physiology Heart and Circulation Physiology

      Volume: 299(5) Pages: 1708-1714

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic Control of Maximal Ventricular Elastance via the Baroreflex and Force-Frequency Relation in Awake Dogs Before and After Pacing Induced Heart Failure.2010

    • Author(s)
      Chen X, Sala-Mercado JA, Hammond RL, Ichinose M, Soltani S, Mukkamala R, O'Leary DS.
    • Journal Title

      American Journal of Physiology Heart and Circulation Physiology

      Volume: 299(1) Pages: 62-69

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of CO2 on the ventilatory sensitivity to rising body temperature during exercise.

    • Author(s)
      Hayashi K, Honda Y, Miyakawa N, Fujii N, Ichinose M, Koga S, Kondo N, Nishiyasu T.
    • Journal Title

      Journal of Applied Physiology

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Reflex cardiovascularcontrol duringexercise:contribution of muscle metaboreflex in humans.2012

    • Author(s)
      Ichinose M
    • Organizer
      Integrated physiology to exercise,exercise training,environment and health(シンポジウム).
    • Place of Presentation
      兵庫県
    • Year and Date
      2012-12-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 動 的足底屈運動時における下腿陰圧負荷が活 動肢血流量および中心循環反応に及ぼす影 響.2012

    • Author(s)
      一 之瀬真志 ,一之瀬智子,西保岳
    • Organizer
      第67回日本体力医学会大会.
    • Place of Presentation
      岐阜県
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Muscle metaboreflex modulates dynamic cardiovascular andcerebrovascular responses to acute hypotension in humans.2012

    • Author(s)
      Ichinose M, Watanabe K, Tsuji Band Nishiyasu T
    • Organizer
      The Systems Biology of Exercise: Cardio-Respiratory and Metabolic Integration.
    • Place of Presentation
      Leeds, United Kingdom.
    • Year and Date
      2012-08-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Muscle Metabore flex Modulates Dynamic Cardiovascularand Cerebrovascular Responsesto Acute Hypotensionin Humans.2012

    • Author(s)
      Ichinose M,Watanabe K,TsujiBand Nishiyasu T
    • Organizer
      American Collegeof Sports Medicine 59th annual meeting
    • Place of Presentation
      SanFrancisco,CA,USA.
    • Year and Date
      2012-06-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Reflex cardiovascular control during exercise: contribution of muscle metaboreflex in humans2012

    • Author(s)
      Ichinose M
    • Organizer
      Integrated physiology to exercise, exercise training, environment and health(シンポジウム)
    • Place of Presentation
      兵庫県
    • Related Report
      2012 Annual Research Report
  • [Presentation] 動的足底屈運動時における下腿陰圧負荷が活動肢血流量および中心循環反応に及ぼす影響2012

    • Author(s)
      一之瀬真志,一之瀬智子,西保 岳
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      岐阜県
    • Related Report
      2012 Annual Research Report
  • [Presentation] 筋からの複合的な求心性入力が発汗反応に及ぼす影響2012

    • Author(s)
      天野達郎,一之瀬真志,三輪樹生,井上芳光,西保 岳,近藤徳彦
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      岐阜県
    • Related Report
      2012 Annual Research Report
  • [Presentation] バトミントン競技選手における血管内皮機能および反射性循環調節に関する研究‐利き腕と非利き腕に着目して‐2012

    • Author(s)
      田原麗衣,渡邊和仁,一之瀬真志,吹田真士,前田 清,西保 岳
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      岐阜県
    • Related Report
      2012 Annual Research Report
  • [Presentation] Muscle metaboreflex modulates dynamic cardiovascular and cerebrovascular responses to acute hypotension in humans2012

    • Author(s)
      Ichinose M, Watanabe K, Tsuji B
    • Organizer
      The Systems Biology of Exercise: Cardio-Respiratory and Metabolic Integration
    • Place of Presentation
      Leeds, United Kingdom.
    • Related Report
      2012 Annual Research Report
  • [Presentation] Muscle Metaboreflex Modulates Dynamic Cardiovascular and Cerebrovascular Responses to Acute Hypotension in Humans2012

    • Author(s)
      Ichinose M, Watanabe K, Tsuji B
    • Organizer
      American College of Sports Medicine 59th annual meeting
    • Place of Presentation
      San Francisco, CA, USA.
    • Related Report
      2012 Annual Research Report
  • [Presentation] 筋代謝受容器刺激時における急性の動脈血圧低下に対する循環応答.2011

    • Author(s)
      一之瀬真志,渡邊和仁,藤井直人,西保岳.
    • Organizer
      第19回日本運動生理学会大会
    • Place of Presentation
      徳島県
    • Year and Date
      2011-08-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 筋代謝受容器刺激時における急性の動脈血圧低下に対する循環応答2011

    • Author(s)
      一之瀬真志, 渡邊和仁, 藤井直人, 西保岳
    • Organizer
      第19回日本運動生理学会大会
    • Place of Presentation
      徳島県
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 筋代謝受容器反射活性時における動脈圧受容器反射による心拍調節機能:活動部位の違いに着目して2011

    • Author(s)
      渡邊和仁, 一之瀬真志, 藤井直人, 西保岳
    • Organizer
      第19回日本運動生理学会大会
    • Place of Presentation
      徳島県
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spontaneous baroreflex control of heart rate during activation of the muscle metaboreflex in the forearm and calf in humans2011

    • Author(s)
      Watanabe K, Ichinose M, Fujii N, Tsuji B, Sugihara A, Niwa T, Nishiyasu T
    • Organizer
      16th Annual Congress of the European College of Sport Science
    • Place of Presentation
      Liverpool, United Kingdom
    • Year and Date
      2011-07-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spontaneous baroreflex control of heart rate during graded activation of the muscle metaboreflex in humans2011

    • Author(s)
      Watanabe K, Ichinose M, Delliaux S, Fujii N, Nishiyasu T
    • Organizer
      Biotechnology and Biological Sciences Research Council-Japanese Partnership Symposium
    • Place of Presentation
      Leeds, United Kingdom
    • Year and Date
      2011-07-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spontaneous baroreflex control of heart rate during graded activation of the muscle metaboreflex in humans2011

    • Author(s)
      Watanabe K, Ichinose M, Delliaux S, Fujii N, Nishiyasu T
    • Organizer
      14th International Conference on Environmental Ergonomics
    • Place of Presentation
      Nafplio, Greece
    • Year and Date
      2011-07-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Muscle metaborefelx modulates dynamic cardiovascular responses to acute hypotension in humans.2011

    • Author(s)
      Ichinose ,Watanabe K,Fujii NaNishiyasu T.
    • Organizer
      American Collegeof Sports Medicine 58th annual meeting.
    • Place of Presentation
      Denver,CO,USA.
    • Year and Date
      2011-06-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Muscle metaborefelx modulates dynamic cardiovascular responses to acute hypotension in humans2011

    • Author(s)
      Ichinose M, Watanabe K, Fujii N, Nishiyasu T
    • Organizer
      American College of Sports Medicine 58th annual meeting
    • Place of Presentation
      Denver, CO, USA
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Muscle Metabore flex Functions during Dynamic Exercisein Humans2010

    • Author(s)
      chinoseM
    • Organizer
      University of Tsukuba,Bodyand Mind Integrative Sciences(BAMIS)project 6th Seminar
    • Place of Presentation
      茨城県.
    • Year and Date
      2010-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Muscle Metaboreflex Functions during Dynamic Exercise in Humans2010

    • Author(s)
      Ichinose M
    • Organizer
      University of Tsukuba, Body and Mind Integrative Sciences(BAMIS)project 6th Seminar
    • Place of Presentation
      筑波大学(招待講演)
    • Year and Date
      2010-09-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 筋代謝受容器反射の活性レベルの差異が循環調節に及ぼす影響2010

    • Author(s)
      渡邊和仁, 一之瀬真志, 藤井直人, 西保岳
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大学
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトの動的運動時における筋代謝受容器反射の特性2010

    • Author(s)
      一之瀬真志,渡邊和仁,藤井直人,西保岳
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉県
    • Year and Date
      2010-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトの動的運動時における筋代謝受容器反射の特性2010

    • Author(s)
      一之瀬真志, 渡邊和仁, 藤井直人, 西保岳
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大学
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 運動時における反射性循環調節の相互作用2010

    • Author(s)
      一之瀬真志
    • Organizer
      運動と循環研究会
    • Place of Presentation
      千葉県
    • Year and Date
      2010-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 運動時における反射性循環調節の相互作用2010

    • Author(s)
      一之瀬真志
    • Organizer
      運動と循環研究会
    • Place of Presentation
      和洋女子大学
    • Year and Date
      2010-09-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Muscle Metabore flex Functions During Dynamic Exercisein Humans2010

    • Author(s)
      Ichinose M,Watanabe K,Delliaux S,Fujii N,Nishiyasu T
    • Organizer
      American Collegeof Sports Medicine 57th annual meeting
    • Place of Presentation
      Baltimore,Maryland,USA.
    • Year and Date
      2010-06-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Muscle Metaboreflex Functions During Dynamic Exercise in Humans2010

    • Author(s)
      Masashi Ichinose, Kazuhito Watanabe, Stephane Delliaux, Naoto Fujii, Takeshi Nishiyasu.
    • Organizer
      American College of Sports Medicine 57th annual meeting
    • Place of Presentation
      Baltimore, Maryland, USA.
    • Year and Date
      2010-06-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Integrative cardiovascular regulation during exercise: interactions between arterial baroreflex and musclemetaboreflex.2010

    • Author(s)
      Ichinose M.
    • Organizer
      The 87th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      岩手県
    • Year and Date
      2010-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Integrative cardiovascular regulation during exercise : interactions between arterial baroreflex and muscle metaboreflex.2010

    • Author(s)
      Ichinose M
    • Organizer
      The 87th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトの運動時における循環調節の特性-ヒトとイヌの筋代謝受容器反射の機能の比較-.2010

    • Author(s)
      一之瀬真志.
    • Organizer
      日本生理人類学会第62回大会
    • Place of Presentation
      大阪府
    • Year and Date
      2010-05-16
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトの運動時における循環調節の特性-ヒトとイヌの筋代謝受容器反射の機能の比較-2010

    • Author(s)
      一之瀬真志
    • Organizer
      日本生理人類学会第62回大会
    • Place of Presentation
      大阪国際大学(招待講演)
    • Year and Date
      2010-05-16
    • Related Report
      2010 Annual Research Report
  • [Book] 身体運動と呼吸・循環機能II部循環機能,14.代謝および圧受容器反射の相互作用2012

    • Author(s)
      一之瀬真志(編集宮村美晴)
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2012 Final Research Report
  • [Book] 身体運動と呼吸・循環機能 宮村美晴編 II部 循環機能,14.代謝および圧受容器反射の相互作用.2012

    • Author(s)
      一之瀬真志
    • Total Pages
      461
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2012 Annual Research Report
  • [Book] 運動生理学のニューエビデンス担当:末梢反射と循環調節2010

    • Author(s)
      一之瀬真志(編集宮村実晴)
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2012 Final Research Report
  • [Book] 運動生理学のニューエビデンス 担当:末梢反射と循環調節2010

    • Author(s)
      一之瀬真志(編集宮村実晴)
    • Total Pages
      462
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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