| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
In this study, we worked on the development of disease prevention methods and the discovery of novel nutrition sensor. As a result, thyroid hormone receptors and sterol regulatory binding proteins SREBPs play animportant role as the transcription factor for the transcriptional regulation of CYP27B1 gene which is vitamin D metabolism enzyme. Further, the development of ectopic calcification in the premature aging mouse models having a phosphorus metabolic abnormalities,revealed the possibility of stanniocalcin 2 contributes as a defense factor.
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