Development of material design for bio-absorbable composites toward tailor made medical treatments
Project/Area Number |
22686014
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Single-year Grants |
Research Field |
Materials/Mechanics of materials
|
Research Institution | Tokyo Metropolitan University |
Principal Investigator |
|
Project Period (FY) |
2010-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2010: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
|
Keywords | 生体吸収性プラスチック / ポリL乳酸 / 生体吸収性複合材料 / 高次構造 / 結晶化 / 配向 / マイクロメカニックス / 損傷力学 |
Research Abstract |
In order to realize a tailor-made medical treatment considering region and degree of disease, mechanical and hydrolysis properties for poly(L-lactic acid)/ tri-calcium phosphate composites were investigated experimentally and analytically as a function of the content of tri-calcium phosphate. Mechanical behavior was predicted based upon modified micromechanics. Molecular weight distributions, as hydrolysis behavior, were analytically predicted considering self-catalytic effect of carboxyl group. Since it is confirmed that variations in mechanical behavior associated with hydrolysis is caused by degradation around interphase between tri-calcium phosphate/ poly(L-lactic acid), mechanical behavior was predicted considering interfacial debonding with hydrolysis. In addition, mechanical properties of the composites were improved with an interfacial treatments.
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Report
(5 results)
Research Products
(41 results)