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roles of serotonin in the body axis formation

Research Project

Project/Area Number 22687016
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionKyoto University

Principal Investigator

MAEGAWA Shingo  京都大学, 大学院・情報学研究科, 助教 (30467401)

Research Collaborator FUJIOKA Shunji  京都大学, 大学院・情報学研究科, 修士学生
TOKUMASU Yudai  京都大学, 総合人間学部, 学部生
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords形成体 / セロトニン / オーガナイザー / 形態形成 / 胚発生
Research Abstract

Serotonin is a well-known neurotransmitter involved in sociality and/or behavior of animal. In the present study, we revealed that Tphd2, a serotonin synthesis emzyme, is expressed in the organizer in zebrafish. In addition, serotonin itself is expressed during gastrulation depending on the organizer. Inhibition of Tphd2 by antisense resulted in shortened body axis. Molecular and developmental studies demonstrated that Thpd2 is required for migration of cells toward to the dorsal region during morphogenesis. Finally, the results clearly indicate that serotonin is involved in early body patterning in zebrafish development.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011 2010

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (4 results)

  • [Journal Article] A novel silk-like shell matrix gene is expressed in the mantle edge of the Pacific oyster prior to shell regeneration2012

    • Author(s)
      J.Takahashi, M.Takagi, Y.Okihana, K.Takeo, T.Ueda, K.Touhata, S.Maegawa, H.Toyohara
    • Journal Title

      Gene

      Volume: 499 Issue: 1 Pages: 130-134

    • DOI

      10.1016/j.gene.2011.11.057

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correct anteroposterior patterning of the zebrafish neurectoderm in the absence of the early dorsal Organizer2011

    • Author(s)
      Mate Varga, Shingo Maegawa, and Eric S. Weinberg
    • Journal Title

      BMC Dev. Biol

      Volume: 11 Issue: 1 Pages: 26-26

    • DOI

      10.1186/1471-213x-11-26

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-Embryo Metabolomics and Systematic Prediction of Developmental Stage in Zebrafish.2011

    • Author(s)
      doi:10.1186/1471-213X-11-26
    • Journal Title

      Z. Naturforsch

      Volume: 66 c Pages: 191-198

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cooling-sensitive TRPM8 is thermostat ofskin temperature against cooling2011

    • Author(s)
      Tajino K, Hosokawa H, Maegawa S, Matsumura K, Dhaka A, Kobayashi S
    • Journal Title

      PLoS One

      Volume: 6 Issue: 3 Pages: e17504-e17504

    • DOI

      10.1371/journal.pone.0017504

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single-embryo metabolomics and systematic prediction of developmental stage in zebrafish.2011

    • Author(s)
      Hayashi S et. al.
    • Journal Title

      Z Naturforsch C.

      Volume: 66 Pages: 191-198

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction and patterning of trunk and tail neural ectoderm by the homeobox gene eve1 in zebrafish embryos2010

    • Author(s)
      Carlos Cruz, Shingo Maegawa, Eric Weinberg, Stephen Wilson, Igor Dawid, and Tetsuhiro Kudoh
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 107(8) Issue: 8 Pages: 3564-3569

    • DOI

      10.1073/pnas.1000389107

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction and patterning of trunk and tail neural ectoderm by the homeobox gene eve1 in zebrafish embryos2010

    • Author(s)
      Carlos Cruz, et al
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 107 Pages: 3564-3569

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Serotonin is involved in embryogenesis in zebrafish2010

    • Author(s)
      Yudai Tokumasu et al
    • Organizer
      2010 the American Society for Cell Biology 50th Annual meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2010-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Visualization of serotonergic neurons in living zebrafish2010

    • Author(s)
      Shunji Fujioka et al.
    • Organizer
      2010 the American Society for Cell Biology 50th Annual meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2010-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Serotonin is involved in embryogenesis in zebrafish2010

    • Author(s)
      Yudai Tokumasu, et al
    • Organizer
      2010 the American Society for Cell Biology 50^<th> Annual meeting
    • Place of Presentation
      Philadelphia, PA, USA
    • Year and Date
      2010-12-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Visualization of serotonergic neurons in living zebrafish2010

    • Author(s)
      Shunji Fujioka, et al
    • Organizer
      2010 the American Society for Cell Biology 50^<th> Annual meeting
    • Place of Presentation
      Philadelphia, PA, USA
    • Year and Date
      2010-12-13
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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