Functional analysis of DNA damage response of transcription factor FOXO1 in lifespan regulation
| Project/Area Number |
22688029
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2010: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
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| Keywords | 老化 / 転写因子 / 紫外線 / DNA損傷修復 / 寿命 / FOXO / 線虫 / 損傷乗り越えDNA複製 / 損傷乗り越え複製 / DNA損傷 / 損傷乗り越え修復 |
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| Research Abstract |
Transcription factor FOXO1 is known to be involved in lifespan extension and anti-aging; however, the molecular mechanism remains unclear. In this study, we found that FOXO1 contributes to tlanslesion DNA synthesis, which serves as the DNA damage response against ultra violet (UV) irradiation. Furthermore, genetic analysis using C. elegans showed that FOXO1/DAF-16 plays a crucial role in UV resistance during larval development. Our finding will help to elucidate the anti-aging mechanism of FOXO1.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Asymmetric arginine dimethylation determines life span in C.elegans by regulating forkhead transcription factor DAF-162011
Author(s)
Takahashi Y., Daitoku H., Hirota K., Tamiya H., Yokoyama A., Kako K., Nagashima Y., Nakamura A., Shimada T., Watanabe S., Yamagata K., Yasuda K., Ishii N., Fukamizu A.
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Journal Title
Cell Metabolism
Volume: 13
Issue: 5
Pages: 505-516
DOI
Related Report
Peer Reviewed
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