|Budget Amount *help
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
The present findings have established the new concept that specific subtypes of hemichannels, i.e., pannexin 1 and connexin 43, at the human blood-brain barrier (BBB) make a significant contribution to the dysfunction of the BBB transport system under acute ischemic conditions. This could raise the potential of the BBB hemichannels as a therapeutic target for brain ischemic damage exaggeration.