Analysis of dendrite specific Rab protein in neuron

• Project/Area Number: 22700324
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Tohoku University
• Principal Investigator: MORI Yasunori 東北大学, 大学院・生命科学研究科, 助教 (80443042)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 分子 / 細胞神経科学 / 神経 / 樹状突起 / 極性 / 小胞輸送 / Rab

Research Abstract

It has been reported that several members of the Rab family small GTPases, which are key mediators of membrane trafficking, regulate axon-specific trafficking events, but little has been elucidated regarding the molecular mechanisms that underlie dendrite-specific membrane trafficking. We showed that Rab17 regulates dendritic morphogenesis and postsynaptic development in mouse hippocampal neurons.

Research Products

• [Journal Article] Small GTPase Rab17 regulates the dendritic morphogenesis and postsynaptic development of hippocampal neurons. (2012)
  • Author(s): Mori, Y., Matsui, T., Furutani, Y., Yoshihara, Y. and Fukuda, M
  • Journal Title: J. Biol. Chem. Volume: 287 Pages: 8963-8973
  • Peer Reviewed
• [Journal Article] Small GTPase Rab17 regulates dendritic morphogenesis and postsynaptic development of hippocampal neurons (2012)
  • Author(s): Mori, Y, Matsui, T., Fumtani, Y, Yoshihara, Y & Fukuda. M
  • Journal Title: J. Biol. Chem Volume: 287 Issue: 12 Pages: 8963-8973
  • DOI: 10.1074/jbc.m111.314385
  • Peer Reviewed
• [Journal Article] Synaptotagmin IV acts as a multi-functional regulator of Ca^<2+>-dependent exocytosis. (2011)
  • Author(s): Mori, Y. and Fukuda, M.
  • Journal Title: Neurochem. Res Volume: 36 Pages: 1222-1227
  • Peer Reviewed
• [Journal Article] Synaptotagmin IV acts as a multi-functional regulator of Ca2+-dependent exocytosis (2011)
  • Author(s): Yasunori Mori, Mitsunori Fukuda
  • Journal Title: Neurochemical Research Volume: 36 Issue: 7 Pages: 1222-1227
  • DOI: 10.1007/s11064-010-0352-7
  • Peer Reviewed
• [Journal Article] Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells. (2010)
  • Author(s): Sato, M, Mori, Y., Matsui, T., Aoki, R., Ohya, M., Yanagihara, Y., Fukuda, M. and Tuboi, T
  • Journal Title: J. Neurochem Volume: 114 Pages: 171-181
  • Peer Reviewed
• [Journal Article] Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells (2010)
  • Author(s): Mai Sato, Yasunori Mori, Takahide Matsui, Ryo Aoki, Manami Oya, Yu Yanagihara, Mitsunori Fukuda, Takashi Tsuboi
  • Journal Title: Journal of Neurochemistry Volume: 114 Pages: 171-81
  • Peer Reviewed
• [Presentation] Small GTPase Rab17 regulates the dendritic morphogenesis and postsynaptic development of hippocampal neurons. (2012)
  • Author(s): Yasunori Mori, Takahide Matsui, Yutaka Furutani, Yoshihiro Yoshihara, Mitsunori Fukuda
  • Organizer: Joint Spring Conference of BSCB/BSDB/JSDB
  • Place of Presentation: at the University of Warwick, Coventry, UK
  • Year and Date: 2012-04-17
• [Presentation] Rab17, a dendrite-specific Rab protein, regulates the dendritic morphogenesis and postsynaptic development of hippocampal neurons. (2011)
  • Author(s): 森靖典、松井貴英、古谷裕、吉原良浩、福田光則
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-13
• [Presentation] Rab17, a dendrite-specific Rab protein, regulates the dendritic morphogenesis and postsynaptic development of hippocampal neurons (2011)
  • Author(s): 森靖典、松井貴英、古谷裕、吉原良浩、福田光則
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-13
• [Presentation] Rab17 regulates dendritic morphologenesis of hippocampal neurons (2011)
  • Author(s): 森靖典、松井貴英、古谷裕、吉原良浩、福田光則
  • Organizer: 第3回新学術領域研究「細胞内ロジスティクス」班会議
  • Place of Presentation: 鳥羽
  • Year and Date: 2011-06-02
• [Remarks]
  • URL: http://www.biology.tohoku.ac.jp/lab-www/fukuda_lab/home-ja.html
• [Remarks]
  • URL: http://www.ac.cyberhome.ne.jp/~fukuda/index.htm
• [Remarks]
  • URL: http://www.biology.tohoku.ac.jp/lab-www/fukuda_lab/home-ja.html