| Project/Area Number |
22700474
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | University of Hyogo |
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Principal Investigator |
YOSHIKI Keisuke 兵庫県立大学, 大学院・工学研究科, 助教 (60432548)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | コラーゲン / 第2高調波発生 / 応力 / MEMS / 生体材料 / ナノバイオ / 共焦点顕微鏡 / 計測工学 / 応用光学 / SHG顕微鏡 / 応力分布 |
|---|
| Research Abstract |
We developed a second harmonic generation(SHG) microscope technic for non-contact and low-invasion observation of internal stress of collagen fibers, which is main components of extracellular matrix, and gives mechanical strength to soft tissue like skin. We demonstrated the potential of the technic by showing that the intensity of SHG light from collagen fibers had a dependence on the internal stress induced by tensile tester on SHG microscope, which focus ultra-short pulsed laser on collagen fibers.
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