Research for the regulation of voluntary exercise and energy metabolism by appetite-regulating factors
| Project/Area Number |
22700693
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MAWATARI Kazuaki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (40352372)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAYA Yutaka 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (50136222)
SAKAUE Hiroshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (60372645)
HARADA Nagamatsu 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40359914)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 自発運動 / 摂食調節因子 / Ghrelin / 内臓脂肪 / 肥満 |
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| Research Abstract |
We established a new animal model called SPORTS(Spontaneously-Running Tokushima-Shikoku) rats, which show high voluntary wheel running and low level of plasma total Ghrelin. The aim of this study was to investigate the in vivo effect of Ghrelin and Obestatin, which are appetite-regulating factors generated from prepro-Ghrelin, on voluntary wheel running and energy metabolism using the SPORTS animal model. We divided SPORTS rats into two groups, which were intramuscularly administrated Saline, Ghrelin, or Ghrelin+ Obestatin for six days(100. g/ kg BW/ day). Voluntary wheel running was significantly decreased in Ghrelin groups. Food intake, body weight, and abdominal visceral fat were significantly increased in Ghrelin groups. Obestatin suppressed Ghrelin-induced food intake, body weight, and abdominal visceral fat gains, but did not have any effect on voluntary wheel running. Our results suggest that Ghrelin and Obestatin may exert different pathway on the voluntary exercise or appetite. Some appetite-regulating factors may regulate voluntary exercise or energy metabolism.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] β-Adrenergic-AMPK Pathway Phosphorylates Acetyl-CoA Carboxylase in a High-epinephrine Rat Model2010
Author(s)
Atsushi Hattori, Kazuaki Mawatari, Satomi Tsuzuki, Emiko Yoshioka, Satomi Toda, Masaki Yoshida, Sonoko Yasui, Hiroko Furukawa, Masaki Morishima, Katsushige Ono, Takamasa Ohnishi, Masayuki Nakano, Nagakatsu Harada, Akira Takahashi, Yutaka Nakaya
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Journal Title
SPORTS. Obesity
Volume: Vol.18、No.1
Pages: 48-54
DOI
Related Report
Peer Reviewed
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[Presentation] 自発運動制御におけるGhrelinの役割2010
Author(s)
戸田聡美, 阪上浩, 谷口康子, 志内哲也, 箕越靖彦, 原田永勝, 馬渡一諭, 中屋豊
Organizer
第53回日本糖尿病学会年次学術集会
Place of Presentation
岡山コンベンションセンター(岡山市)
Year and Date
2010-05-28
Related Report
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