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Research for the regulation of voluntary exercise and energy metabolism by appetite-regulating factors

Research Project

Project/Area Number 22700693
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied health science
Research InstitutionThe University of Tokushima

Principal Investigator

MAWATARI Kazuaki  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (40352372)

Co-Investigator(Renkei-kenkyūsha) NAKAYA Yutaka  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (50136222)
SAKAUE Hiroshi  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (60372645)
HARADA Nagamatsu  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40359914)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords自発運動 / 摂食調節因子 / Ghrelin / 内臓脂肪 / 肥満
Research Abstract

We established a new animal model called SPORTS(Spontaneously-Running Tokushima-Shikoku) rats, which show high voluntary wheel running and low level of plasma total Ghrelin. The aim of this study was to investigate the in vivo effect of Ghrelin and Obestatin, which are appetite-regulating factors generated from prepro-Ghrelin, on voluntary wheel running and energy metabolism using the SPORTS animal model. We divided SPORTS rats into two groups, which were intramuscularly administrated Saline, Ghrelin, or Ghrelin+ Obestatin for six days(100. g/ kg BW/ day). Voluntary wheel running was significantly decreased in Ghrelin groups. Food intake, body weight, and abdominal visceral fat were significantly increased in Ghrelin groups. Obestatin suppressed Ghrelin-induced food intake, body weight, and abdominal visceral fat gains, but did not have any effect on voluntary wheel running. Our results suggest that Ghrelin and Obestatin may exert different pathway on the voluntary exercise or appetite. Some appetite-regulating factors may regulate voluntary exercise or energy metabolism.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (13 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (6 results) Book (3 results)

  • [Journal Article] Telmisartan increases localization of glucose transporter 4 to the plasma membrane and increases glucose uptake via peroxisome proliferator-activated receptorγin 3T3-L1 adipocytes2011

    • Author(s)
      Hiroko Furukawa, Kazuaki Mawatari, Kei Koyama, Sonoko Yasui, Ran Morizumi, Takaaki Shimohata, Nagakatsu Harada, Akira Takahashi, Yutaka Nakaya
    • Journal Title

      European Journal of Pharmacology

      Volume: Vol.660、No.2-3 Issue: 2-3 Pages: 485-491

    • DOI

      10.1016/j.ejphar.2011.04.008

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 自発運動制御におけるGhrelinの役割2011

    • Author(s)
      馬渡一諭
    • Journal Title

      肥満研究

      Volume: 16S Pages: 128-128

    • Related Report
      2011 Annual Research Report
  • [Journal Article] β-Adrenergic-AMPK Pathway Phosphorylates Acetyl-CoA Carboxylase in a High-epinephrine Rat Model2010

    • Author(s)
      Atsushi Hattori, Kazuaki Mawatari, Satomi Tsuzuki, Emiko Yoshioka, Satomi Toda, Masaki Yoshida, Sonoko Yasui, Hiroko Furukawa, Masaki Morishima, Katsushige Ono, Takamasa Ohnishi, Masayuki Nakano, Nagakatsu Harada, Akira Takahashi, Yutaka Nakaya
    • Journal Title

      SPORTS. Obesity

      Volume: Vol.18、No.1 Issue: 1 Pages: 48-54

    • DOI

      10.1038/oby.2009.145

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] β-Adrenergic-AMPK Pathway Phosphorylates Acetyl-CoA Carboxylase in a High-epinephrine Rat Model, SPORTS2010

    • Author(s)
      Kazuaki Mawatari
    • Journal Title

      Obesity

      Volume: 18 Pages: 48-54

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 自発運動制御におけるGhrelinの役割2011

    • Author(s)
      戸田聡美, 阪上浩, 谷口康子, 原田永勝, 馬渡一諭, 中屋豊, 志内哲也, 箕越靖彦
    • Organizer
      第14回日本病態栄養学会年次学術集会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-01-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 自発運動制御におけるGhrelinの役割2010

    • Author(s)
      戸田聡美, 阪上浩, 谷口康子, 原田永勝, 馬渡一諭, 中屋豊, 志内哲也, 箕越靖彦
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      前橋テルサ(前橋市)
    • Year and Date
      2010-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 自発運動制御におけるGhrelinの役割2010

    • Author(s)
      戸田聡美, 阪上浩, 谷口康子, 志内哲也, 箕越靖彦, 原田永勝, 馬渡一諭, 中屋豊
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Year and Date
      2010-05-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 自発運動制御におけるGhrelinの役割2010

    • Author(s)
      馬渡一諭
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山県岡山市
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 自発運動制御におけるGhrelinの役割2010

    • Author(s)
      戸田聡美, 阪上浩, 谷口康子, 志内哲也, 箕越靖彦, 原田永勝, 馬渡一諭, 中屋豊
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      アスティ徳島(徳島市)
    • Year and Date
      2010-05-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 自発運動制御におけるGhrelinの役割2010

    • Author(s)
      馬渡一諭
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      徳島県徳島市
    • Year and Date
      2010-05-23
    • Related Report
      2010 Annual Research Report
  • [Book] 栄養科学シリーズNEXT「応用栄養学」(第3版)2012

    • Author(s)
      中坊幸弘, 木戸康博, 馬渡一諭(他24名)
    • Publisher
      講談社サイエンティフィック
    • Related Report
      2011 Final Research Report
  • [Book] 栄養教育論演習2012

    • Author(s)
      岡崎光子, 饗場直美, 馬渡一諭(他13名)
    • Publisher
      建帛社
    • Related Report
      2011 Final Research Report
  • [Book] 栄養科学シリーズNEXT応用栄養学第3版2012

    • Author(s)
      馬渡一諭
    • Total Pages
      182
    • Publisher
      講談社サイエンティフィック
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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