| Project/Area Number |
22700706
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Research Collaborator |
OTSUJI Yutaka 産業医科大学, 医学部, 教授 (30264427)
TAKEUCHI Masaaki 産業医科大学, 医学部, 准教授 (30236434)
SONODA Shinjo 産業医科大学, 医学部 (90299610)
NAKATA Sei 産業医科大学, 医学部, 非常勤医師 (20535223)
ADACHI Tetsuo 岐阜薬科大学, 薬学部, 教授 (40137063)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生活習慣病 / メタボリック症候群 / 細胞外スーパーオキシドジスムターゼ / 酸化ストレス / インスリン抵抗性 |
|---|
| Research Abstract |
We examined a relationship between metabolic syndrome and extracellular superoxide dismutase, a major antioxidant in the cardiovascular system, in middle-aged Japanese male workers. This study demonstrated that plasma levels of extracellular superoxide dismutase were significantly increased in subjects with metabolic syndrome than in those without. This finding indicates that a therapy targeted to extracellular superoxide dismutase may be a new strategy for metabolic syndrome.
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