Study of novel lipid-lowering effects of sesaminol, a sesame lignan
| Project/Area Number |
22700752
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Miyazaki |
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Principal Investigator |
NISHIZONO Shoko 宮崎大学, 産学・地域連携センター, 准教授 (40336970)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ゴマリグナン / セサミノールアグリコン / 脂質代謝 / ラット / 栄養学 / 食品 / 脂質 / 植物 / 農林水産品 / 脂質代謝調節 / セサミノール / トリグリセリド濃度 / コレステロール濃度 |
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| Research Abstract |
Sesaminol is a sesame lignin and is present most exclusively occurring as sesaminol triglucoside in sesame seed. In this study, effect of sesaminol aglycone on lipid metabolism was investigated in Sprague-Dawley rats. Four-week-old male rats were fed diets containing 0～ 0. 20% sesaminol. After 4 week-feeding period, serum and liver lipids levels were determined. We reported, for the first time, that dietary sesaminol significantly reduce(s) serum and hepatic lipids, especially triglyceride levels in a dose dependent manner ; this reduction appeared to be greater than those of a well-known other functional components. The mechanism responsible for the observed reduction in the concentration of triglyceride may be due to a reciprocal response in the enzyme activities involved in fatty acid synthesis and oxidation.
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Report
(3 results)
Research Products
(1 results)
