| Project/Area Number |
22710106
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIBATA Osamu 長崎国際大学, 薬学部薬学科, 教授 (10117129)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 表面・界面物性 / 複合材料 / 肺サーファクタント / ナノ医薬 / 超薄膜 / 表面張力 / 表面電位 / 蛍光顕微鏡 / ブリュースター角顕微鏡 / 呼吸窮迫症候群 / 未熟児 / DPPC |
|---|
| Research Abstract |
The model peptide in our pulmonary surfactant preparations changes its secondary structure from α-helix to β-sheet upon lateral compression. However, in the presence of anionic lipids such as phosphatidylglycerol and palmitic acid, the conversion of the structure is found to be prevented from the spectroscopic aspect.
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