New animal model of depression using water maze learning situation in mice
| Project/Area Number |
22730593
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental psychology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
DOE Nobutaka 兵庫医科大学, 医学部, 非常勤講師 (00434879)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 実験系心理学 / 行動学 / 神経科学 / ストレス / 脳神経疾患 / 動物モデル / うつ病 |
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| Research Abstract |
We have developed a new animal model of depression by modifying the Morris water maze learning situation in mice. It is generally believed that mice placed in a pool filled with opaque water will learn to escape onto a platform hidden below the water surface. However, if the difficulty of the task is increased, some of the mice gradually cease to swim and become immobile ; this response indicates a depressive state. In this research, the validity of our experimental method as a depression model was verified by demonstrating the phenotypic differences between "nonhelpless" mice(designated"Winner") and "helpless"mice(designated"Loser"). Compared with nonhelpless mice, helpless mice showed lower spontaneous locomotor activity in their home cage. In addition, helpless mice exhibited impaired neurogenesis in the hippocampus and increased serum levels of proinflammatory cytokines, such as IL-1α, IL-1β and TNF-α.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Genotoxicity-suppressing effect of aqueous extract of Connarus ruber cortex2011
Author(s)
Nakamura, T., Nakai, M., Ookubo, K., Kitamura, Y., Doe, N., Hattori, S., Murakami, N., Yamamoto, A., Honda, G., & Sasaki, Y. F.
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Journal Title
Genes and Environment
Volume: 33
Pages: 81-88
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] Immunodeficiency reduces neural stem/progenitor cell apoptosis and enhances neurogenesis in the cerebral cortex after stroke2010
Author(s)
Saino, O., Taguchi, A., Nakagomi, T., Nakano-Doi, A., Kashiwamura, S., Doe, N., Nakagomi, N., Soma, T., Yoshikawa, H., Stern, D. M., Okamura, H., & Matsuyama, T.
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Journal Title
Journal of Neuroscience Research
Volume: 88
Issue: 11
Pages: 2385-2397
DOI
Related Report
Peer Reviewed
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[Presentation] Edaravone is effective to ameliorate the sensory neurologic deficit developed in chronic phase of cerebral infarction in mice2011
Author(s)
Matsuyama, T., Doe, N., Nakagomi, T., Nakano-Doi, A., Saino, O., Takata, M., Lu, S., Mimura, O., Tachibana, H., Taguchi, A.
Organizer
XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function & Xth International Conference on Quantification of Brain Function and PET, Brain 2011
Place of Presentation
Barcelona, Spain
Related Report
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[Presentation] CD25-positive T lymphocytes are key immunomodulators of neurogenesis after stroke2010
Author(s)
Matsuyama, T., Saino, O., Nakagomi, T., Nakano-Doi, A., Takata, M., Kashiwamura, S., Doe, N., Nakagomi, N., Mimura, O., & Taguchi, A.
Organizer
7th World Stroke Congress
Place of Presentation
Soeal, Koria
Related Report
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