Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Research Abstract |
We established a practical synthesis of cyclic bis(3'-5')diadenylic acid (c-di-AMP), which was recently identified as a second messenger monitoring DNA integrity during sporulation in the soil bacterium Bacillus subtilis. Using the synthetic c-di-AMP obtained by ourmethod, we revealed that c-di-AMP promotes the cell division of Chlamydomonas reinhardtii, a kind of freshwater green algae. The three 2'-modified c-di-AMPs synthesized by our method were also found to enhance the cell division.
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