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Plasma separation chip driven by capillary force

Research Project

Project/Area Number 22760104
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Production engineering/Processing studies
Research InstitutionRitsumeikan University

Principal Investigator

SAKAMOTO Hiroaki  立命館大学, 総合理工学研究機構, ポストドクトラルフェロー (70552454)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords血漿分離 / マイクロ流路 / 微細加工 / マイクロTAS / 電気化学 / 血液検査 / 表面処理 / アクリル成形 / μ-TAS / 毛細管力 / 表面修飾 / μTAS / オンサイト分析 / ホットエンボス
Research Abstract

In this study, a microdevice driven by capillary action has been developed for the high-throughput on-chip separation of plasma from a drop of blood. In order to separate plasma from blood, we designed 2μm deep array channels to filter the red blood cells. After injection of a blood sample, the plasma flowed rapidly and arrived at the outlet within 3 min, demonstrating a 100% separation ratio of red blood cells. Because the proposed blood separation device is driven solely by capillary action, it is possible to miniaturize it as an entire system.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] Plasma separation PMMA device driven by capillary force controlling surface wettability2012

    • Author(s)
      Hiroaki Sakamoto, Ranko Hatsuda, Kazuhiro Miyamura, and Susumu Sugiyama
    • Journal Title

      Micro & Nano Letters

      Volume: 7 Pages: 64-67

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrochemical Selective Detection of Uric Acid Using a Copper-modified Carbon Electrode2011

    • Author(s)
      Hiroaki Sakamoto, Ranko Hatsuda, Kazuhiro Miyamura, Haruki Shiraishi and Susumu Sugiyama
    • Journal Title

      Analytical Science

      Volume: 27 Pages: 333-335

    • NAID

      10027906515

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 電気化学計測を行うマイクロ流路の最適な構造設計2011

    • Author(s)
      坂元博昭、初田蘭子、宮村和宏、白石晴樹、杉山進
    • Organizer
      第28回センサ・マイクロマシンと応用システム
    • Place of Presentation
      タワーホール船堀東京都
    • Year and Date
      2011-09-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 電気化学計測を行うマイクロ流路の最適な構造設計2011

    • Author(s)
      坂元博昭、初田蘭子、宮村和宏、白石晴樹、杉山進
    • Organizer
      第28回「センサ・マイクロマシンと応用システム」シンポジウム
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2011-09-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Blood plasma separation PMMA device using capillary phenomenon and its application for Point Of Care Testing device2010

    • Author(s)
      Hiroaki SAKAMOTO, Ranko HATSUDA, Kazuhiro MIYAMURA, Haruki SHIRAISHI and Susumu SUGIYAMA
    • Organizer
      Pacifichem2010, 18^<th>
    • Place of Presentation
      Hawaii, U. S. A.
    • Year and Date
      2010-12-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Blood plasma separation PMMA device using capillary phenomenon and its application for Point Of Care Testing device2010

    • Author(s)
      Hiroaki SAKAMOTO, Ranko HATSUDA, Kazuhiro MIYAMURA, Haruki SHIRAISHI, Susumu SUGIYAMA
    • Organizer
      2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
    • Place of Presentation
      アメリカ、ハワイ
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Design and fabrication blood plasma PMMA chip using capillary phenomenon2010

    • Author(s)
      Hiroaki SAKAMOTO, Ranko HATSUDA, Kazuhiro MIYAMURA, Susumu SUGIYAMA
    • Organizer
      2010 Int'l Symposium on Micro-NanoMechatronics and Human Science & Micro-Nano Global COE
    • Place of Presentation
      愛知県 名古屋大学
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Design and fabrication blood plasma PMMA chip using capillary phenomenon2010

    • Author(s)
      Hiroaki SAKAMOTO, Ranko HATSUDA, Kazuhiro MIYAMURA, Haruki SHIRAISHI and Susumu SUGIYAMA
    • Organizer
      2010 Int' l Symposium on Micro-NanoMechatronics and Human Science & Micro-Nano Global COE(MHS2010), 8^<th>
    • Place of Presentation
      愛知県
    • Year and Date
      2010-10-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 銅修飾カーボン電極による尿酸の選択的検出2010

    • Author(s)
      坂元博昭、初田蘭子、宮村和宏、白石晴樹、杉山進
    • Organizer
      日本分析化学会第59年会
    • Place of Presentation
      東北大学宮城県
    • Year and Date
      2010-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 銅修飾カーボン電極による尿酸の選択的検出2010

    • Author(s)
      坂元博昭、初田蘭子、宮村和宏、白石晴樹、杉山進
    • Organizer
      日本分析化学会第59年会
    • Place of Presentation
      宮城県 東北大学
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血漿分離、スクリーニング、検出を集積したオンサイト型血液診断装置の開発2010

    • Author(s)
      坂元博昭、初田蘭子、宮村和宏、白石晴樹、杉山進
    • Organizer
      第20回マイクロエレクトロニクスシンポジウム
    • Place of Presentation
      立命館大学滋賀県
    • Year and Date
      2010-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 「血漿分離、スクリーニング、検出」を集積したオンサイト型血液診断装置の開発2010

    • Author(s)
      坂元博昭、初田蘭子、宮村和宏、白石晴樹、杉山進
    • Organizer
      第20回マイクロエレクトロニクスシンポジウム
    • Place of Presentation
      滋賀県 立命館大学
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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