Mammalian viviparity developed by retrotransposon-derived gene, Peg10
Project/Area Number |
22770004
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Genetics/Genome dynamics
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
ONO Ryuichi 東京医科歯科大学, 難治疾患研究所, 助教 (10401358)
|
Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | レトロトランスポゾン / 胎盤 / ゲノムインプリンティング |
Research Abstract |
I have previously demonstrated that Peg10, a paternally expressed imprinted gene, is derived from retrotransposon and has an essential function in placental development. To reveal the function of Peg10, I established TS(Trophoblast Stem) cell lines from Peg10 KO mice. By comparing the gene expressionbetween Peg10 KO TS cell lines and wild type TS cell lines, I identified Peg10 down regulated genes and Peg10 binding DNA sequence.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Identification of tammar wallaby SIRH12, derivedfrom a marsupial-specific retrotransposition event2011
Author(s)
Ono, R., Kuroki, Y., Naruse, M., Ishii, M., Iwasaki, S., Toyoda, A., Fujiyama, A., Shaw, G., Renfree, MB., Kaneko-Ishino, T., Ishino, F
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Journal Title
DNA Research
Volume: 18(4)
Pages: 211-219
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