Mechanisms of formation and maintenance of signaling center during brain patterning
| Project/Area Number |
22770206
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | (A)細胞分化 / 菱脳 / 境界 / ゼブラフィッシュ / イメージング / Eph-ephrin / コンパートメント / 未分化性維持 / ニューロン分析 |
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| Research Abstract |
In this study, I examined the processes of rhombomere-boundary formation in the Pax6 mutant rat hindbrain. This study suggests that Pax6 may repress neuronal differentiation through Notch signaling pathway in the rhombomere-boundary cells. I also analyzed cell behavior in the hindbrain of EphA4/ephrinB3b double knockdown-zebrafish embryos using high resolution-confocal time-lapse imaging. GFP^+ interface cells at r3/4 boundary abnormally elongated along the A-P axis and then migrated into r4 region, suggesting that EphA4/ephrinB3b signaling is required for sharpening rhombomere boundaries via regulation of cell migration and cell polarity.
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Report
(3 results)
Research Products
(9 results)
