Wnt-dependent regulation of neuro-mesodermal precursor cells
| Project/Area Number |
22770214
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 胚葉形成 / 原腸形成 / 体節形成 / 体軸幹細胞 / 転写制御 / 神経誘導 / 幹細胞 |
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| Research Abstract |
Vertebrate develops by addition of posterior tissues. It is well known that Wnt signal has an important role in this process. However, the mechanism of Wnt action in this process remains unknown.
I found that there is a common precursor cell deriving neural and mesodermal cell in the primitive streak region. Two transcription factors, SOX2 and TBX6, control the fate toward neural primordial cells and mesodermal cells, respectively. The expression of these genes is regulated by Wnt signal.
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Report
(3 results)
Research Products
(24 results)
