| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Vertebrate develops by addition of posterior tissues. It is well known that Wnt signal has an important role in this process. However, the mechanism of Wnt action in this process remains unknown.
I found that there is a common precursor cell deriving neural and mesodermal cell in the primitive streak region. Two transcription factors, SOX2 and TBX6, control the fate toward neural primordial cells and mesodermal cells, respectively. The expression of these genes is regulated by Wnt signal.
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