The evolution of coding triplet repeats in human genome
| Project/Area Number |
22770239
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical anthropology
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| Research Institution | The Graduate University for Advanced Studies |
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Principal Investigator |
GOJOBORI Jun 総合研究大学院大学, 先導科学研究科, 助教 (00506800)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | アミノ酸リピート / 不確定領域 / トリプレットリピート / 進化 / 機能的制約 / 人類学 / ゲノム / 脊椎動物 |
|---|
| Research Abstract |
It is proposed that triplet repeats in coding regions are more likely to form disordered region in protein structure. It is suggested that disordered regions evolve faster. In this study, I examine the relationship between the evolutionary rate and protein structure for triplet repeats in coding regions. I showed that the repeats in non-disordered region evolved faster than disordered region during primate evolution. Here I revealed primate specific evolution on coding triplet repeats.
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Report
(4 results)
Research Products
(8 results)
