The evolution of coding triplet repeats in human genome

• Project/Area Number: 22770239
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Physical anthropology
• Research Institution: The Graduate University for Advanced Studies
• Principal Investigator: GOJOBORI Jun 総合研究大学院大学, 先導科学研究科, 助教 (00506800)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: アミノ酸リピート / 不確定領域 / トリプレットリピート / 進化 / 機能的制約 / 人類学 / ゲノム / 脊椎動物

Research Abstract

It is proposed that triplet repeats in coding regions are more likely to form disordered region in protein structure. It is suggested that disordered regions evolve faster. In this study, I examine the relationship between the evolutionary rate and protein structure for triplet repeats in coding regions. I showed that the repeats in non-disordered region evolved faster than disordered region during primate evolution. Here I revealed primate specific evolution on coding triplet repeats.

Research Products

• [Journal Article] Comparative Genetics of the Poly-Q Tract of Ataxin-1 and Its Binding Protein PQBP-1 (2012)
  • Author(s): Kurosaki T, Gojobori J, Ueda S
  • Journal Title: Biochem Genet Volume: 50 Issue: 3-4 Pages: 309-317
  • DOI: 10.1007/s10528-011-9473-1
  • Peer Reviewed
• [Journal Article] An autosomal analysis gives no genetic evidence for complex speciation of humans and chimpanzees (2012)
  • Author(s): 山道真人、五條堀淳、印南秀樹
  • Journal Title: Molecular Biology and Evolution Volume: 29巻 Issue: 1 Pages: 145-156
  • DOI: 10.1093/molbev/msr172
  • Peer Reviewed
• [Journal Article] Elevated evolutionary rate in genes with homopolymeric amino acid repeats constituting nondisordered structure. (2011)
  • Author(s): Jun Gojobori
  • Journal Title: Molecular Biology and Evolution Volume: 28 Pages: 543-550
  • Peer Reviewed
• [Journal Article] Elevated evolutionary rate in genes with homopolymeric amino acid repeats constituting non-disordered structure (2010)
  • Author(s): Gojobori J. and Ueda S.
  • Journal Title: Mol. Biol. Evol. Volume: 10 Issue: 1 Pages: 1093-1093
  • DOI: 10.1093/molbev/msq225
  • Peer Reviewed
• [Presentation] Elevated Evolutionary Rate in Genes with Non-disordered Homopolymeric Amino Acid Repeats During Primate Evolution (2012)
  • Author(s): Gojobori T, Ueda S
  • Organizer: Okazaki Biological Conference
  • Place of Presentation: 岡崎コンファレンスセンター(招待講演)
  • Year and Date: 2012-03-19
• [Presentation] Elevated Evolutionary Rate in Genes with Non-disordered Homopolymeric Amino Acid Repeats During Primate Evolution (2012)
  • Author(s): Gojobori J. and Ueda S.
  • Organizer: Okazaki Biological Conference
  • Place of Presentation: 岡崎
• [Presentation] Evolutionary rates are elevated for genes with homopolymeric amino acid repeats constituting nondisordered structure (2011)
  • Author(s): Gojobori J, Ueda S
  • Organizer: SMBE2011
  • Place of Presentation: 京都大学
  • Year and Date: 2011-07-27
• [Presentation] Evolutionary rates are elevated for genes with homopolymeric amino acid repeats constituting nondisordered structure (2011)
  • Author(s): Gojobori J. and Ueda S
  • Organizer: SMBE2011
  • Place of Presentation: 京都