| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
We investigated transcriptional regulatory systems of Bacillus subtilis that respond to plant-derived aromatic compounds, flavonoids and indole-3-acetic acid (IAA). While Fur is known as a transcriptional repressor that derepresses its target genes on iron starvation, our study demonstrated that Fur also responds to specific flavonoids such as fisetin, resulting in the partial derepression of its target genes. We also analyzed the functional mechanism and the physiological role of the flavonoid-responsive LmrA/QdoR regulatory system, which had been identified in our previous study. Moreover, we identified the YhbI regulatory system as an IAA-responsive one and performed its characterization.
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