| Project/Area Number |
22790022
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
|
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 天然物合成 / 逆電子要請型Diels-Alder反応 / 生合成模倣 / かご状骨格 / 超高圧反応 / Masked o-benzoquinone / masked o-benzoquinone |
|---|
| Research Abstract |
The purpose of this study was the development of efficient synthetic methodof natural products possessing an unprecedentedly complex carbon skeleton. The efficient synthesis ofnatural products including bicyclo [2.2.2] octanes was performed by reverse-electron-demand Diels-Alderreaction of the MOB, which can be easily prepared from phenols. Using this methodology, we haveachieved the construction of the highly-functionalized carbon skeleton of target compounds, chloropupukeananin and atropurpuran.
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