Development of novel domino reaction utilizing feature of highly reactive imtermediate 'borylenamine'
| Project/Area Number |
22790028
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
UEDA Masafumi 神戸薬科大学, 薬学部, 講師 (00340935)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 合成化学 / ラジカル反応 / 共役イミン / ドミノ反応 / [3,3]-シグマトロピー転位 / benzofuro[2,3-b]pyrrole / ラクタム / 付加反応 / トリエチルボラン / 有機銅試薬 / 計算化学 |
|---|
| Research Abstract |
Reagent dependent regioselective additions to dual activated alkyne have been developed. The reaction with alkyl radical afforded β-addition product, while the reaction with organocuprate gave α-adduct with both high regio-and stereoselectivities. These reactions were applied to domino and one-pot reaction, providing tetrasubstituted and functionalized alkenes. Computational studies have been demonstrated to rationalize the selectivity.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Benzyl Radical Addition Reaction through the Homolytic Cleavage of a Benzylic C-H Bond2011
Author(s)
Ueda, M.; Kondoh, E.; Ito, Y.; Shono, H.; Kakiuchi, M.; Ichii, Y.; Kimura, T.; Miyoshi, T.; Naito, T.; Miyata, O.
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Journal Title
Org. Biomol. Chem.
Volume: 9(7)
Pages: 2062-2064
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