Development and transdermal formulation of intradermal siRNA delivery system using functional peptides for atopic dermatitis therapy
| Project/Area Number |
22790049
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | siRNA / 機能性ペプチド / AT1002 / ハイドロゲル / アトピー性皮膚炎 / 核酸DDS / RelA / 液晶製剤 / セリシン / Re1A / 経皮製剤 / タイトジャンクション / 細胞透過性ペプチド |
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| Research Abstract |
In this study, to develop the intradermal siRNA delivery system using functional peptides, the intradermal siRNA delivery and therapeutic effect of siRNA in atopic dermatitis (AD) induced mice were investigated. Combination of cell-penetrating peptide and tight junction opener increased the intradermal siRNA delivery andtherapeutic effect of anti-NF kB siRNA in AD mice. In addition, the therapeutic effects by functional peptides/siRNA containing hydrogel increased compared with the peptides/siRNA solution.
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Report
(4 results)
Research Products
(28 results)
