Regulation of hematopoietic stem cell activation by dendritic cells
| Project/Area Number |
22790054
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YOTSUMOTO Satoshi 東京医科歯科大学, 難治疾患研究所, 特任助教 (30318191)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 造血幹細胞 / 樹状細胞 / インターフェロン / 細胞周期 / ウィルス感染 / Type I IFN / Type II IFN / ウイルス感染 / mobilization / SOCS1/3 / IL-27 / pDC / cDC |
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| Research Abstract |
We here showed that type I and II IFN directly activated HSC and induced cell cycle entry and quiescence in HSC during virus infection. The IFN-mediated HSC activation was dependent on not only DC and NK cells, but also other IFN-producing cells. Moreover, IFN is important for inhibition of HSC mobilization and induction of HSC-autonomous immunity by IFN-induced proteins against intracellular virus.
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Report
(3 results)
Research Products
(7 results)
