The role of serine protease granzyme on the induction of itch in atopic dermatitis
| Project/Area Number |
22790063
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
ANDOH Tsugunobu 富山大学, 大学院・医学薬学研究部(薬学), 准教授 (50333498)
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| Research Collaborator |
KIMURA Yusuke 富山大学, 薬学部薬学科, 学生
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 痒み / アトピー性皮膚炎 / プロテアーゼ / グランザイム / 皮膚 / NCマウス / T細胞 / 掻き動作 / プロテアーゼ活性化受容体 |
|---|
| Research Abstract |
The precious mechanisms of itch in atopic dermatitis are unclear. Since T cells infiltrate into the skin with atopic dermatitis and the proteases are also involved in the severe itch, we focused proteases produced by T cells for demonstrating the itch mechanisms in the dermatitis. It was demonstrated that granzyme A, which is one of 11 subtypes of granzymes, elicited itch through the activation of proteinase-activated receptor 2
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Report
(4 results)
Research Products
(29 results)
