Novel pathophysiological mechanisms involving the aberrant trafficking of sodium pump in human cancer cells
| Project/Area Number |
22790204
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | University of Toyama |
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Principal Investigator |
FUJII Takuto 富山大学, 大学院・医学薬学研究部(薬学), 助教 (50567980)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 癌 / ナトリウムポンプ / トラフィッキング / 原形質膜 / 小胞 / 癌細胞 / Na^+,K^+-ATPase α3-isoform / 小胞体 / 分泌小胞 |
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| Research Abstract |
Na+, K+-ATPaseα3-isoform(α3NaK) is abnormally expressed in various types of human cancer cells.α3NaK is not localized in plasma membrane, but in intracellular vesicles in which rab10 is present. In vitro and in vivo studies using human and mouse cancer cells showed thatα3NaK may be involved in the mechanisms of cancer cell survival and growth.
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Report
(3 results)
Research Products
(50 results)
