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Pathophysiological relationship ofmitochondria to neuronal death during brain ischemia

Research Project

Project/Area Number 22790256
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionKagoshima University

Principal Investigator

KANBE Yuki  鹿児島大学, 大学院・医歯学総合研究科, 助教 (60549913)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords神経細胞死 / 細胞内情報伝達 / ミトコンドリア / 脳神経疾患 / シグナル伝達 / 脳・神経疾患
Research Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) increases neurite outgrowth in many kind of neuronal cells, but signaling via its receptor PACAP-specific receptor has not been fully characterized. Because mitochondria also play an important role in neurodevelopment including dendritic branching, axonal guidanceand neurite outgrowth, we examined whether mitochondria contribute to PACAP-mediated neurite outgrowth. Present data suggest that mitochondrial activation plays a key role in PACAP-induced neurite outgrowth via a signaling pathway that includes PAC1R, PKA, andPgc1α.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (35 results)

All 2013 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (24 results) Remarks (4 results)

  • [Journal Article] N-arachidonoyl glycine induces macrophage apoptosis via GPR182012

    • Author(s)
      Takenouchi R, Inoue K, Kambe Y, Miyata A
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 418(2) Pages: 366-371

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22266325

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Mitochondrial Activation in PACAP Dependent Neurite Outgrowth2012

    • Author(s)
      Kambe Y, Miyata A
    • Journal Title

      J Mol Neurosci

      Volume: 48(3) Pages: 550-557

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22460784

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of mitochondrial uncoupling protein-2 in cytotoxicity mediated by acquired N-methyl-d-aspartate receptor channels2012

    • Author(s)
      Fukumori R, Takarada T, Kambe Y, Nakazato R, Fujikawa K, Yoneda Y
    • Journal Title

      Neurochem Int.

      Volume: 61 Pages: 498-505

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22490607

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory mechanism of PAC1 gene expression via Sp1 by nerve growth factor in PC12 cells2012

    • Author(s)
      Miura A, Odahara N, Tominaga A, Inoue K, Kambe Y, Kurihara T, Miyata A
    • Journal Title

      FEBS Lett

      Volume: 586 Pages: 1731-1735

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22609358

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of mitochondrial uncoupling protein-2 in cytotoxicity mediated by acquired N-methyl-d-aspartate receptor channels2012

    • Author(s)
      Fukumori, R.
    • Journal Title

      Neurochem Int

      Volume: 61 Pages: 498-505

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory mechanism of PAC1 gene expression via Sp1 by nerve growth factor in PC12 cells2012

    • Author(s)
      Miura, A.
    • Journal Title

      FEBS Lett

      Volume: 586 Pages: 1731-5

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A possible pivotal role of mitochondrial free calcium in neurotoxicity mediated by N-methyl-d-aspartate receptors in cultured rat hippocampal neurons2011

    • Author(s)
      Kambe Y, Nakamichi N, Takarada T, Fukumori R, Nakazato R, Hinoi E, Yoneda Y
    • Journal Title

      Neurochem Int

      Volume: 59(1) Pages: 10-20

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/21669242

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] C-TYPE NATRIURETIC PEPTIDE MODULATES THE PERMEABILITY OF BLOOD-BRAIN BARRIER2013

    • Author(s)
      Manoj Bohara, Yuki Kambe, Takashi Kurihara, Tetsuya Nagayama, Kazunori Arita, Atsuro Miyata
    • Organizer
      第86回 日本薬理学会年会
    • Place of Presentation
      福岡国際会議場,福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] C-TYPE NATRIURETIC PEPTIDE MODULATES THE PERMEABILITY OF BLOOD-BRAIN BARRIER2013

    • Author(s)
      Manoj Bohara
    • Organizer
      第86会 日本薬理学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] PACAP による神経突起伸展促進作用におけるミトコンドリアの寄与2012

    • Author(s)
      神戸悠輝,宮田篤郎
    • Organizer
      ニューロフォーラム
    • Place of Presentation
      鹿児島大学鶴陵会館,鹿児島
    • Year and Date
      2012-07-10
    • Related Report
      2012 Final Research Report
  • [Presentation] PACAP による神経突起伸展促進作用におけるミトコンドリアの寄与2012

    • Author(s)
      神戸悠輝,宮田篤郎
    • Organizer
      GPCR 研究会
    • Place of Presentation
      日本科学未来館 みらい CAN ホール,東京
    • Year and Date
      2012-05-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Involvement of mitochondria in PACAP dependent neurite outgrowth2012

    • Author(s)
      Yuki Kambe,Atsuro Miyata
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans at the Ernest N. Morial Convention Center,アメリカ
    • Related Report
      2012 Final Research Report
  • [Presentation] Sp1 serves pivotal role in negative regulation of PAC1 gene expression by involvement of transglutaminase 22012

    • Author(s)
      Ayako Miura, Yuki Kambe, Kazuhiko Inoue, Takashi Kurihara, Atsuro Miyata
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans at the Ernest N. Morial Convention Center,アメリカ
    • Related Report
      2012 Final Research Report
  • [Presentation] PACAPによる神経突起伸展促進作用におけるミトコンドリアの寄与2012

    • Author(s)
      神戸悠輝
    • Organizer
      GPCR研究会
    • Place of Presentation
      日本科学未来館 みらいCANホール
    • Related Report
      2012 Annual Research Report
  • [Presentation] PACAPによる神経突起伸展促進作用におけるミトコンドリアの寄与2012

    • Author(s)
      神戸悠輝
    • Organizer
      ニューロフォーラム
    • Place of Presentation
      鹿児島大学 鶴陵会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] Involvement of mitochondria in PACAP dependent neurite outgrowth2012

    • Author(s)
      Yuki Kambe
    • Organizer
      Society for Neuroscience, 2012
    • Place of Presentation
      New Orleans at the Ernest N. Morial Convention Center.
    • Related Report
      2012 Annual Research Report
  • [Presentation] Sp1 serves pivotal role in negative regulation of PAC1 gene expression by involvement of transglutaminase 22012

    • Author(s)
      Ayako Miura
    • Organizer
      Society for Neuroscience, 2012
    • Place of Presentation
      New Orleans at the Ernest N. Morial Convention Center.
    • Related Report
      2012 Annual Research Report
  • [Presentation] PAC1 受容体を介した神経突起形成メカニズムにおけるミトコンドリア機能調節2011

    • Author(s)
      神戸悠輝,井上和彦,栗原崇,宮田篤郎
    • Organizer
      第64回日本薬理学会西南部会
    • Place of Presentation
      KKR ホテル博多,福岡
    • Year and Date
      2011-11-20
    • Related Report
      2012 Final Research Report
  • [Presentation] PAC1受容体を介した神経突起形成メカニズムにおけるミトコンドリア機能調節2011

    • Author(s)
      神戸悠輝, 井上和彦, 栗原崇, 宮田篤郎
    • Organizer
      第64回日本薬理学会西南部会
    • Place of Presentation
      KKRホテル博多,福岡
    • Year and Date
      2011-11-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neuro2a 細胞の神経突起形成過程における Pgc1 の細胞内輸送によるシグナル伝達機構の解明2011

    • Author(s)
      神戸悠輝,井上和彦,栗原崇,宮田篤郎
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜,横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] PAC1 遺伝子の負の発現調節機序の解析2011

    • Author(s)
      三浦綾子,井上和彦,神戸悠輝,栗原崇,宮田篤郎
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜,横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Pgc1 α translocation may be one of the key factors for neurite outgrowth in neurons2011

    • Author(s)
      Yuki Kambe, Kazuhiko Inoue, Takashi Kurihara and Atsuro Miyata
    • Organizer
      8th Conference of Asian Society for Mitochondrial Research and Medicine
    • Place of Presentation
      市民文化ホール,鹿児島
    • Related Report
      2012 Final Research Report
  • [Presentation] Intra-cellular translocation of Pgc1α is involved in PACAP induced neurite outgrowth in neuronal cells2011

    • Author(s)
      Yuki Kambe, Kazuhiko Inoue, Takashi Kurihara and Atsuro Miyata
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      瑠璃光,石川
    • Related Report
      2012 Final Research Report
  • [Presentation] INVOLVEMENT OF MITOCHONDRIA IN PACAP-PAC1 DEPENDENT NEURITE OUTGROWTH2011

    • Author(s)
      Yuki Kambe, Kazuhiko Inoue, Takashi Kurihara, Atsuro Miyata
    • Organizer
      10th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      Hilton Eilat Queen of Sheba Hotel,イスラエル
    • Related Report
      2012 Final Research Report
  • [Presentation] Pgc1α translocation may be one of the key factors for neurite outgrowth in neurons2011

    • Author(s)
      Yuki Kambe, Kazuhiko Inoue, Takashi Kurihara, Atsuro Miyata
    • Organizer
      8th Conference of Asian Society for Mitochondrial Research and Medicine
    • Place of Presentation
      市民文化ホール,鹿児島
    • Related Report
      2011 Annual Research Report
  • [Presentation] Intra-cellular translocation of Pgc1a is involved in PACAP in duced neurite outgrowth in neuronal cells2011

    • Author(s)
      Yuki Kambe, Kazuhiko Inoue, Takashi Kurihara, Atsuro Miyata
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      瑠璃光,石川
    • Related Report
      2011 Annual Research Report
  • [Presentation] INVOLVEMENT OF MITOCHONDEIA IN PACAP-PAC1 DEPENDENT NEURITE OUTGROWTH2011

    • Author(s)
      Yuki Kambe, Kazuhiko Inoue, Takashi Kurihara, Atsuro Miyata
    • Organizer
      10th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      Hilton Eilat Queen of Sheba Hotel,イスラエル
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neuro2a細胞の神経突起形成過程におけるPgc1の細胞内輸送によるシグナル伝達機構の解明2011

    • Author(s)
      神戸悠輝, 井上和彦, 栗原崇, 宮田篤郎
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)(誌上開催)
    • Related Report
      2010 Annual Research Report
  • [Presentation] PAC1遺伝子の負の発現調節機序の解析2011

    • Author(s)
      三浦綾子, 井上和彦, 神戸悠輝, 栗原崇, 宮田篤郎
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)(誌上開催)
    • Related Report
      2010 Annual Research Report
  • [Presentation] From mitochondria to nucleus, Pgc-1 translocation may be one of the key factors for neurite extension in N2a cells2010

    • Author(s)
      Yuki Kambe, Atsuro Miyata
    • Organizer
      40^<th> annual meeting Neuroscience 2010
    • Place of Presentation
      SanDiego, CA, USA
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] From mitochondria to nucleus, Pgc-1 translocation may be one of the key factors for neurite extension in N2a cells2010

    • Author(s)
      Yuki Kambe and Atsuro Miyata
    • Organizer
      40th annual meeting Neuroscience
    • Place of Presentation
      SanDiego, アメリカ
    • Related Report
      2012 Final Research Report
  • [Remarks] ホームページ

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~pharmaco/

    • Related Report
      2012 Final Research Report
  • [Remarks] 生体情報薬理学

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~pharmaco/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~pharmaco/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~pharmaco/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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