Synaptic formation and maturation regulated by membrane trafficking leading to higher function of the nervous system
| Project/Area Number |
22790293
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SAKANE Ayuko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (60509777)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脳・神経系形成 / 高次神経機能獲得 / シナプス形成・成熟 / 小胞輸送 / Rabファミリー低分子量G蛋白質 / 脳・神経系 |
|---|
| Research Abstract |
Rab family small G proteins serve as molecular switches in the regulation of vesicular trafficking. In this study, we focus on the role and mode of action of Rab3A, Rab13, and their related proteins in synaptic formation and maturation, leading to higher function of the nervous system. As to Rab3A, we found the mice lacking Rabconnectin, the Rab3A-related protein, exhibit neuronal dysfunction, probably because of misformation of synaptic organization. We also found that the Rab13-JRAB system regulates the reorganization of actin cytoskeleton during neurite extension in PC12 cells. Our results suggest that this system may simultaneously coordinate vesicle transport and actin cytoskeletal reorganization in synaptic formation followed by maturation.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Expression of RASSF6 in kidney and the implication of RASSF6 and the Hippo pathway in the sorbitol-induced apoptosis in renal proximal tubular epithelial cells2012
Author(s)
Withanage, K., Nakagawa, K., Ikeda, M., Kurihara, H., Kudo, T., Yang, Z., Sakane, A., Sasaki, T. and Hata, Y
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Journal Title
J. Biochem
Volume: 152(1)
Issue: 1
Pages: 111-119
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain2010
Author(s)
Tabata, K., Matsunaga, K., Sakane, A., Sasaki, T., Noda, T. and Yoshimori, T
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Journal Title
Mol. Biol. Cell
Volume: 21(23)
Issue: 23
Pages: 4162-4173
DOI
Related Report
Peer Reviewed
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