Research of liver fibrosis associated with liver stem cells

• Project/Area Number: 22790341
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Kanazawa University
• Principal Investigator: IKEDA Hiroko 金沢大学, 附属病院, 准教授 (10447675)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 肝線維化 / ステム細胞 / 病理

Research Abstract

The expression of Delta-like protein(DLK)-1 in hepatic progenitor/stem cell has been known in animal experiments, whereas the upregulation of DLK1 in hepatic stellate cells has been reported and implied relation to fibrosis. I examined the expression of DLK1 in human tissue. As results, The expression of DLK1 was demonstrated in liver cancer associated with stem-cell origin. It was suggested that DLK1 could be cancer stem-cell marker of the liver.

Research Products

• [Journal Article] α-Fetoprotein-producing gastric carcinoma and combined hepatocellular and cholangiocarcinoma show similar morphology but different histogenesis with respect to SALL4 expression (2012)
  • Author(s): Ikeda H, Nakanuma Y, 他7名
  • Journal Title: Hum Pathol Volume: (in press) Issue: 11 Pages: 1955-1963
  • DOI: 10.1016/j.humpath.2011.11.022
  • Peer Reviewed
• [Journal Article] Bile duct expression of pancreatic and duodenal homeobox 1 in perihilar cholangiocarcinogenesis (2012)
  • Author(s): Igarashi S, Ikeda H, 他6名
  • Journal Title: Histopathology Volume: (in press) Issue: 2 Pages: 266-276
  • DOI: 10.1111/j.1365-2559.2012.04218.x
  • Peer Reviewed
• [Journal Article] Epidermal growth factor induces cytokeratin 19 expression accompanied by increased growth abilities in human hepatocellular carcinoma (2011)
  • Author(s): Yoneda N, Ikeda H, 他8名
  • Journal Title: Lab Invest Volume: 91 Issue: 2 Pages: 262-72
  • DOI: 10.1038/labinvest.2010.161
  • Peer Reviewed
• [Journal Article] Intrahepatic cholangiocarcinoma arising in chronic advanced liver disease and the cholangiocarcinomatous component of hepatocellular cholangiocarcinoma share common phenotypes and cholangiocarcinogenesis (2011)
  • Author(s): Xu J, Ikeda H, 他6名
  • Journal Title: Histopathology Volume: 59 Issue: 6 Pages: 1090-9
  • DOI: 10.1111/j.1365-2559.2011.04058.x
  • Peer Reviewed
• [Presentation] 混合型肝癌におけるDelta-like protein(DLK)-1発現の免疫組織学的検討 (2012)
  • Author(s): 池田博子, 他
  • Organizer: 日本病理学会総会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2012-04-27
• [Presentation] 混合型肝癌の新WHO分類と肝ステム細胞関連分子発現に関する病理学的検討 (2011)
  • Author(s): 池田博子, 他
  • Organizer: 日本肝臓学会総会
  • Place of Presentation: グランパシフィック(東京)
  • Year and Date: 2011-06-08
• [Presentation] 表層進展を示す胆管癌の病理組織学的検討 (2011)
  • Author(s): 池田博子, 他
  • Organizer: 日本病理学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-04-28
• [Presentation] AFP産生胃癌と混合型肝癌における肝ステム細胞および胚細胞系ステム細胞関連分子発現の検討 (2011)
  • Author(s): 池田博子, 他
  • Organizer: 日本病理学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-04-27