Epigenetic regulation of differentiation induction and Epithelial mesenchymaltransition of thyroid cancer

• Project/Area Number: 22790342
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: University of Yamanashi
• Principal Investigator: KONDO Tetsuo 山梨大学, 大学院・医学工学総合研究部, 准教授 (30334858)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: エピジェネティクス / 甲状腺癌 / 分子病理 / エピジェネティク

Research Abstract

In the thyroid, Thyroid transcription factor-1 (TTF-1) is essential for thyroidorganogenesis and governs thyroid functions by regulating various thyroid-specificgenes. Previously, we showed that epigenetics is involved with inactivation of TTF-1in thyroid

Research Products

• [Journal Article] 甲状腺癌の遺伝子異常と分子病理診断 (2012)
  • Author(s): 近藤哲夫, 加藤良平
  • Journal Title: 最新医学 Volume: 67 Pages: 419-427
• [Journal Article] 甲状腺癌の分子メカニズム 最近の知見. (2012)
  • Author(s): 近藤哲夫
  • Journal Title: 病理と臨床 Volume: 31 Pages: 50-56
• [Journal Article] Transcription factor Runx2 is a regulator of epithelial-mesenchymal transition and invasion in thyroid carcinomas (2012)
  • Author(s): Niu D-F
  • Journal Title: Lab Invest Volume: 92 Pages: 1181-1190
  • Peer Reviewed
• [Presentation] Aberrant Expression of theRunx Family Genes in Thyroid Carcinomas (2012)
  • Author(s): Tetsuo Kondo, Dongfeng Niu, TadaoNakazawa, Tomonori Kawasaki, NaokiOishi, Kunio Mochizuki, Tetsu Yamane,Ryohei Katoh
  • Organizer: The 101st Annual meeting of United States and Canadian Academy of Pathology(USCAP)
  • Place of Presentation: Vancouver, Canada
• [Presentation] 甲状腺乳頭癌充実亜型 (2012)
  • Author(s): 近藤哲夫
  • Organizer: 第45回甲状腺外科学術集会
  • Place of Presentation: 横浜
• [Presentation] 甲状腺癌におけるエピジェネティクス異常と癌の分化誘導に関する研究 (2011)
  • Author(s): 近藤哲夫
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
• [Presentation] AGenome-wide Screening of Promoter DNAMethylation Reveals Differential Profiles ofFollicular-cell Derived Thyroid Neoplasms (2011)
  • Author(s): Tetsuo Kondo, Tadao Nakazawa, TomonoriKawasaki, Kunio Mochizuki, Dong-FengNiu, Tetsu Yamane and Ryohei Katoh
  • Organizer: The 100th Annual meeting of United Statesand Canadian Academy of Pathology(USCAP)
  • Place of Presentation: San Antonio, USA
• [Presentation] Expression of Adenosine Receptors inThyroid Carcinoma (2011)
  • Author(s): Tetsuo Kondo, Tadao Nakazawa, TomonoriKawasaki, Kunio Mochizuki, Dong-FengNiu, Tetsu Yamane, Ryohei Katoh
  • Organizer: The 100th Annualmeeting of United States and CanadianAcademy of Pathology (USCAP)
  • Place of Presentation: San Antonio, USA
• [Presentation] Epigenetic Dysregulation in Thyroid cancer. (2010)
  • Author(s): Tetsuo Kondo
  • Organizer: Korean Endocrine Society
  • Place of Presentation: 韓国テグ市
  • Year and Date: 2010-11-20
• [Presentation] Epigenetic Dysregulation inThyroid cancer. Symposium (2010)
  • Author(s): Kondo T
  • Organizer: the annualmeeting of the Korean Endocrine Society
  • Place of Presentation: Daegu, Korea
• [Presentation] Overexpression of AdenosineReceptor A1 (ADORA1) Regulates ThyroidCancer Cell Invasion (2010)
  • Author(s): Tetsuo Kondo, DeFu Ma, DongFeng Niu,Tadao Nakazawa, Tomonori Kawasaki,Kunio Mochizuki, Tetsu Yamane, RyoheiKatoh
  • Organizer: The 14th InternationalCongress of Endocrinology (ICE 2010)
  • Place of Presentation: Kyoto, Japan
• [Presentation] 甲状腺転写因子TTF-1のエピジェネティクス制御 (2010)
  • Author(s): 近藤哲夫
  • Organizer: 第51回日本組織細胞学会
  • Place of Presentation: 東京
• [Presentation] 甲状腺転写因子TTF-1 のエピジェネティクス制御と癌の分化誘導に関する研究 (2010)
  • Author(s): 近藤哲夫
  • Organizer: 第15回山梨科学アカデミー総会
  • Place of Presentation: 山梨
• [Presentation] 病理診断のための免疫組織化学法 (2010)
  • Author(s): 近藤哲夫
  • Organizer: 第35回組織細胞化学講習会
  • Place of Presentation: 山梨
• [Presentation] 甲状腺濾胞癌の病理 (2010)
  • Author(s): 近藤哲夫, 中澤匡男, 望月邦夫, 川崎朋範, 山根徹, 加藤良平
  • Organizer: 第14回日本内分泌病理学会学術総会
  • Place of Presentation: 京都
• [Book] 遺伝性甲状腺癌 (2011)
  • Author(s): 坂本穆彦、廣川満良編
  • Publisher: 分光堂
• [Book] 病気の分子形態学 (2011)
  • Author(s): 日本臨床分子形態学会編
  • Publisher: 学際企画
• [Book] 病理診断のための免疫組織化学 (2010)
  • Author(s): 日本組織細胞化学編
  • Publisher: 中西印刷
• [Remarks] 研究成果に関するwebページ
  • URL: http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar/3_58/47EAB2789A01B6A4.html
• [Remarks] 山梨大学研究者総覧： 近藤哲夫
  • URL: http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar/3_58/47EAB2789A01B6A4.html
• [Remarks] 山梨大学医学部人体病理学講座
  • URL: http://www.med.yamanashi.ac.jp/clinical_basic/pathol02/
• [Remarks] 研究成果に関するwebページ
  • URL: http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar/3_58/47EAB2789A01B6A4.html