| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Mechanism for cross-presentation of tumor antigen was elucidated in the induction of tumor-antigen specific killer T cells by the antigen-loaded DCs in tumor bearing mice. IL-6, a major cytokine produced under tumor-bearing state, significantly reduced antigen-presenting ability by DCs. Neuropeptide signaling through Neurokinin-2 receptor(NK2R) was closely related with the function of DCs in Type 1 immune responses. In the near future, development of effective generation of tumor-antigen specific T cells by regulation of DC function would be a promising strategy for cancer immunotherapy
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