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Visualization of influenza virus progeny vRNP complex and analysis of cytoplasmic machineries responsible for polarized vRNP trafficking.

Research Project

Project/Area Number 22790438
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Virology
Research InstitutionKitasato University

Principal Investigator

MOMOSE Fumitaka  北里大学, 大学院・感染制御科学府, 講師 (90332204)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsインフルエンザウイルス / 微小管 / 宿主因子 / モノクローナル抗体 / ライブセルイメージング / 低分子量GTP結合タンパク質 / リサイクリングエンドソーム / RNP複合体 / タンパク質導入 / 微小管輸送 / 極性輸送
Research Abstract

This study revealed that Rab11-positive recycling endosomes(RE) participate in the polarized trafficking of influenza A virus ribonucleoprotein complexes(vRNP) to the apical plasma membrane. The targeting of vRNP to the RE depends on the specific interaction between viral RNA dependent RNA polymerase on vRNP and GTP-bound active Rab11.This RE dependent apical transport of vRNP also requires class II Rab11 effector proteins such as Rab11-FIP3/4.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (14 results) Remarks (1 results)

  • [Journal Article] Epitope mapping of neutralizing monoclonal antibody in avian influenza A H5N1 virus hemagglutinin2012

    • Author(s)
      Ohkura T, Kikuchi Y, Kono N, Itamura S, Komase K, Momose F, Morikawa Y
    • Journal Title

      Biochem.Bioph.Res.Co.

      Volume: 418 Issue: 1 Pages: 38-43

    • DOI

      10.1016/j.bbrc.2011.12.108

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apical transport of influenza A virus ribonucleoprotein requires Rab11-positive recycling endosome2011

    • Author(s)
      Momose F., et al.
    • Journal Title

      PLoS ONE

      Volume: 6 Issue: 6 Pages: e21123-e21123

    • DOI

      10.1371/journal.pone.0021123

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Replication-coupled and host factor-mediated encapsidation of the influenza virus genome by viral nucleoprotein2011

    • Author(s)
      Kawaguchi A., et al
    • Journal Title

      J.Virol.

      Volume: 85 Issue: 13 Pages: 6197-6204

    • DOI

      10.1128/jvi.00277-11

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apical transport of influenza A virus ribonucleoprotein requires Rab11-positive recycling endosome2011

    • Author(s)
      Fumitaka Momose, et al
    • Journal Title

      PLoS ONE

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of vesicular trafficking system in membrane targeting of the progeny influenza virus genome2010

    • Author(s)
      Shuichi Jo, Atsushi Kawaguchi, Naoki Takizawa, Yuko Morikawa, Fumitaka Momose, Kyosuke Nagata
    • Journal Title

      Microbes Infect

      Volume: 12巻 Issue: 12-13 Pages: 1079-1084

    • DOI

      10.1016/j.micinf.2010.06.011

    • NAID

      120007137839

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of vesicular trafficking system in membrane targeting of the progeny influenza virus genome2010

    • Author(s)
      Jo S, Kawaguchi A, Takizawa N, Morikawa Y, Momose F, Nagata K.
    • Journal Title

      Microbes and Infection

      Volume: 12 Pages: 1079-1084

    • NAID

      120007137839

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Rab11陽性リサイクリングエンドソームによるインフルエンザウイルスゲノム-タンパク質複合体の極性輸送2011

    • Author(s)
      百瀬文隆, 関本哲也, 大倉喬, 森川裕子
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Rab11陽性リサイクリングエンドソームによるインフルエンザウイルスゲノムータンパク質複合体の極性輸送2011

    • Author(s)
      百瀬文隆, 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Apical transport of influenza a virus ribonucleoprotein requires Rab11-positive recycling endosome2011

    • Author(s)
      Fumitaka Momose, Tetsuya Sekimoto, Takashi Ohkura, Shuichi Jo, Atsushi Kawaguchi, Kyosuke Nagata, Yuko Morikawa
    • Organizer
      15th International Congress of Virology
    • Place of Presentation
      札幌市
    • Year and Date
      2011-09-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Epitope mapping of neutralizing antibody in avian influenza A H5N1 virus hemagglutinin and construction of its single-chain variable fragment2011

    • Author(s)
      Takashi Ohkura, Yuji Kikuchi, Naoko Kono, Shigeyuki Itamura, Katsuhiro Komase, Fumitaka Momose, Yuko Morikawa
    • Organizer
      15th International Congress of Virology
    • Place of Presentation
      札幌市
    • Year and Date
      2011-09-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Apical transport of influenza a virus ribonucleoprotein requires Rab11-positive recycling endosome2011

    • Author(s)
      Fumitaka Momose, et al
    • Organizer
      15th International Congress of Virology
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Epitope mapping of neutralizing antibody in avian influenza A H5N1 virus hemagglutinin and construction of its single-chain variable fragment2011

    • Author(s)
      Takashi Ohkura, et al
    • Organizer
      15th International Congress of Virology
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] インフルエンザウイルス子孫vRNP複合体の極性輸送を担う輸送小胞および宿主因子の同定2010

    • Author(s)
      百瀬文隆, 関本哲也, 大倉喬, 森川裕子
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-07
    • Related Report
      2011 Final Research Report
  • [Presentation] インフルエンザウイルス子孫vRNP複合体の極性輸送を担う輸送小胞および宿主因子の同定2010

    • Author(s)
      百瀬文隆、関本哲也、大倉喬、森川裕子
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸国際展示場(兵庫)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] インフルエンザウイルス子孫vRNP複合体の極性輸送を担う輸送小胞および宿主因子の探索2010

    • Author(s)
      百瀬文隆, 大倉喬, 森川裕子
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島市
    • Year and Date
      2010-11-08
    • Related Report
      2011 Final Research Report
  • [Presentation] インフルエンザウイルス子孫vRNP複合体の極性輸送を担う輸送小胞および宿主因子の探索2010

    • Author(s)
      百瀬文隆、大倉喬、森川裕子
    • Organizer
      第58回 日本ウイルス学会学術集会
    • Place of Presentation
      あわぎんホール(徳島)
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] インフルエンザウイルスRNAゲノム-タンパク質複合体の可視化による細胞質内輸送機構の解析2010

    • Author(s)
      百瀬文隆
    • Organizer
      第58回日本ウイルス学会学術集会シンポジウム
    • Place of Presentation
      徳島市
    • Year and Date
      2010-11-07
    • Related Report
      2011 Final Research Report
  • [Presentation] インフルエンザウイルスRNAゲノム-タンパク質複合体の可視化による細胞質内輸送機構の解析2010

    • Author(s)
      百瀬文隆
    • Organizer
      第58回 日本ウイルス学会学術集会
    • Place of Presentation
      あわぎんホール(徳島)(シンポジウム、招待講演)
    • Year and Date
      2010-11-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Live-cell imaging of the cytoplasmic trafficking of progeny influenza viral ribonucleoprotein complexes2010

    • Author(s)
      Fumitaka Momose, Tetsuya Sekimoto, Yuko Morikawa
    • Organizer
      14th International Conference on Negative Strand Viruses
    • Place of Presentation
      Bruges, Belgium
    • Year and Date
      2010-06-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Live-cell imaging of the cytoplasmic trafficking of progeny influenza viral ribonucleoprotein complexes.2010

    • Author(s)
      Fumitaka Momose, Tetsuya Sekimoto, Yuko Morikawa
    • Organizer
      14th International Conference on Negative Strand Viruses
    • Place of Presentation
      Bruges, Belgium
    • Year and Date
      2010-06-21
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kitasato-u.ac.jp/lisci/

    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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