Role of chemokine receptor CXCR3 on generation and maintenance of memory CD8 T cells
Project/Area Number |
22790453
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Immunology
|
Research Institution | The University of Tokyo |
Principal Investigator |
KURACHI Makoto 東京大学, 大学院・医学系研究科, 助教 (00396722)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 免疫記憶 / CD8陽性T細胞 / CXCR3 / エフェクター分化 / 脾臓辺縁帯 / 抗原特異的CD8陽性T細胞 / メモリー細胞 / ワクチン / ウイルス免疫 |
Research Abstract |
It is not known how early lymphocyte distribution after infection has an impact on this process. We demonstrate that the chemokine receptor CXCR3 is involved in promoting CD8^+T cell commitment to an effector fate rather than a memory fate by regulating T cell recruitment to an antigen/inflammation site.
|
Report
(3 results)
Research Products
(10 results)