Function of claudins in Aire-expressing medullary thymic epithelial cells
| Project/Area Number |
22790458
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
HAMAZAKI Yoko 京都大学, 医学研究科, 准教授 (10362477)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | T細胞分化 / 胸腺 / 自己免疫疾患 / 胸腺上皮細胞 / クローディン / Aire / Ｔ細胞分化 |
|---|
| Research Abstract |
To investigate the function of claudin (Cld)-3, 4 in thymic epithelial cells, we first madesingle KO mice for each gene. There was no obvious defect in each single KO mice; thus we next tried to make double KO mice. Since the distance of each gene on genome is only 40Kbp, we made a strategy in which Cld3 Tg vector was introduced into Cld4KO ES cells. We have succeded in making double KO mice and now are analyzing the phenotypes on thymic organogenesis and T cell development.
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Report
(3 results)
Research Products
(53 results)
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[Journal Article] Claudin-4 isinduced in thymocytes of late CD4/CD8 doublepositive stage by E2A and promotes abT cellreceptor.mediated positive selection2011
Author(s)
Kawai. K. Hamazaki, Y., Fujita, H., Fujita,A., Sato, T., Moriwaki, K., Furuse, M., Fujimoto,T., Agata, Y. and Minato, N
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Journal Title
Proc. Nat. Acad. Sci. USA
Volume: 108(10)
Issue: 10
Pages: 4075-4080
DOI
Related Report
Peer Reviewed
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[Journal Article] Spa-1 (Sipa1) controlsthe invasion and metastasis of human prostatecancers via Rap signal2011
Author(s)
Shimizu Y, Hamazaki Y, Hattori M, Doi K,Terada Y, Kobayashi T, Toda Y, Yamasak T,Inoue T, Kajita Y, Atsushi M, Kamba T, MikamiY, Kamoto T, Yamada T, Ogawa O, Minato Nand Nakamura E
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Journal Title
Cancer Science
Volume: 102
Issue: 4
Pages: 828-836
DOI
Related Report
Peer Reviewed
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[Journal Article] SPA-1 controls the invasion and metastasis of human prostate cancer2011
Author(s)
Shimizu Y, Hamazaki Y, Hattori M, Doi K, Terada N, Kobayashi T, Toda Y, Yamasaki T, Inoue T, Kajita Y, Maeno A, Kamba T, Mikami Y, Kamoto T, Yamada T, Kanno T, Yoshikawa K, Ogawa O, Minato N, Nakamura E
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Journal Title
Cancer Sci
Volume: 102(4)
Pages: 828-36
NAID
Related Report
Peer Reviewed
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